fbpx
Connect with us

The Conversation

Modern surgery began with saws and iron hands – how amputation transformed the body in the Renaissance

Published

on

theconversation.com – Heidi Hausse, Assistant Professor of History, Auburn – 2024-06-17 07:13:41

Modern surgery began with saws and iron hands – how amputation transformed the body in the Renaissance

Amputees in 16th century Europe commissioned iron hands from artisans, many of whom had never made prostheses before.

Lernestål, Erik, Livrustkammaren/SHM, CC BY-SA

Heidi Hausse, Auburn University

The human body has many replaceable parts, ranging from artificial hearts to myoelectric feet. What makes this possible is not just complicated technology and delicate surgical procedures. It’s also an idea — that humans can and should alter ‘ bodies in supremely difficult and invasive ways.

Where did that idea from?

Scholars often depict the American Civil War as an early watershed for amputation techniques and artificial limb design. Amputations were the most common operation of the war, and an entire prosthetics industry developed in response. Anyone who has seen a Civil War film or TV show has likely watched at least one scene of a surgeon grimly approaching a wounded soldier with saw in hand. Surgeons performed 60,000 amputations during the war, spending as little as three minutes per limb.

Yet, a momentous change in practices surrounding limb loss started much earlier – in 16th and 17th century Europe.

Illustration of mechanical iron hand, cross-sectioned to reveal the gears beneath the flesh

The surgeon Ambroise Paré printed a Parisian locksmith’s design for a mechanical iron hand in the 16th century.

Instrumenta chyrurgiae et icones anathomicae/Ambroise Paré via Wellcome Collection

As a historian of early modern medicine, I explore how Western attitudes toward surgical and artisanal interventions in the body started transforming around 500 years ago. Europeans went from hesitating to perform amputations and few options for limb prostheses in 1500 to multiple amputation methods and complex iron hands for the affluent by 1700.

Amputation was seen as a last resort because of the high risk of . But some Europeans started to believe they could use it along with artificial limbs to shape the body. This break from a millennia-long tradition of noninvasive healing still influences modern biomedicine by giving physicians the idea that crossing the physical boundaries of the patient’s body to drastically change it and embed technology into it could be a good thing. A modern hip replacement would be unthinkable without that underlying assumption.

Surgeons, gunpowder and the printing press

Early modern surgeons passionately debated where and how to cut the body to fingers, toes, arms and legs in ways medieval surgeons hadn’t. This was partly because they confronted two new developments in the Renaissance: the spread of gunpowder warfare and the printing press.

Surgery was a craft learned through apprenticeship and years of traveling to train under different masters. Topical ointments and minor procedures like setting broken bones, lancing boils and stitching wounds filled surgeons’ day-to-day practice. Because of their danger, major operations like amputations or trepanations – drilling a hole in the skull – were rare.

Widespread use of firearms and artillery strained traditional surgical practices by tearing bodies apart in ways that required immediate amputation. These weapons also created wounds susceptible to infection and gangrene by crushing tissue, disrupting blood flow and introducing debris — ranging from wood splinters and metal fragments to scraps of clothing — deep into the body. Mangled and gangrenous limbs forced surgeons to choose between performing invasive surgeries or letting their patients die.

The printing press gave surgeons grappling with these injuries a means to spread their ideas and techniques beyond the battlefield. The procedures they described in their treatises can sound gruesome, particularly because they operated without anesthetics, antibiotics, transfusions or standardized sterilization techniques.

Parchment sketch illustrating multiple types of hand amputations, including with a mallet and chisel

A 17th century treatise instructs surgeons to use a mallet and chisel among other amputation methods.

Johannes Scultetus/Universitätsbibliothek Heidelberg

But each method had an underlying rationale. Striking off a hand with a mallet and chisel made the amputation quick. Cutting through desensitized, dead flesh and burning away the remaining dead matter with a cautery iron prevented patients from bleeding to death.

While some wanted to save as much of the healthy body as possible, others insisted it was more important to reshape limbs so patients could use prostheses. Never before had European surgeons advocated amputation methods based on the placement and use of artificial limbs. Those who did so were coming to see the body not as something the surgeon should simply preserve, but rather as something the surgeon could mold.

Amputees, artisans and artificial limbs

As surgeons explored surgical intervention with saws, amputees experimented with making artificial limbs. Wooden peg devices, as they’d been for centuries, remained common lower limb prostheses. But creative collaborations with artisans were the driving force behind a new prosthetic technology that began appearing in the late 15th century: the mechanical iron hand.

Written sources reveal little about the experiences of most who survived limb amputation. Survival rates may have been as low as 25%. But among those who made it through, artifacts show improvisation was key to how they navigated their environments.

Photograph of an iron hand, the wrist to forearm composed of an open metal framework

A wearer operated this 16th century iron hand by pressing down on the fingers to lock them and pressing the release button at the top of the wrist to free them.

Bonnevier, Helena, Livrustkammaren/SHM, CC BY-SA

This reflected a world in which prosthetics were not yet “medical.” In the U.S. today, a doctor’s prescription is necessary for an artificial limb. Early modern surgeons sometimes provided small devices like artificial noses, but they didn’t design, make or fit prosthetic limbs. Furthermore, there was no occupation comparable to today’s prosthetists, or care professionals who make and fit prostheses. Instead, early modern amputees used their own resources and ingenuity to have ones made.

Iron hands were improvised creations. Their movable fingers locked into different positions through internal spring-driven mechanisms. They had lifelike details: engraved fingernails, wrinkles and even flesh-toned paint.

Wearers operated them by pressing down on the fingers to lock them into position and activating a release at the wrist to free them. In some iron hands the fingers move together, while in others they move individually. The most sophisticated are flexible in every joint of every finger.

Complex movement was more for impressing observers than everyday practicality. Iron hands were the Renaissance precursor to the “bionic-hand arms race” of today’s prosthetics industry. More flashy and high-tech artificial hands – then and now – are also less affordable and user-friendly.

This technology drew from surprising places, including locks, clocks and luxury handguns. In a world without today’s standardized models, early modern amputees commissioned prostheses from scratch by venturing into the craft market. As one 16th century contract between an amputee and a Genevan clockmaker attests, buyers dropped into the shops of artisans who’d never made a prosthesis to see what they could concoct.

Because these materials were often expensive, wearers tended to be wealthy. In fact, the introduction of iron hands marks the first time period when European scholars can readily distinguish between people of different social classes based on their prostheses.

Powerful ideas

Iron hands were important carriers of ideas. They prompted surgeons to think about prosthesis placement when they operated and created optimism about what humans could achieve with artificial limbs.

But scholars have missed how and why iron hands made this impact on medical culture because they’ve been too fixated on one kind of wearer – knights. Traditional assumptions that knights used iron hands to hold the reins of their horses offer only one narrow view of surviving artifacts.

A famous example colors this interpretation: the “second hand” of the 16th century German knight Götz von Berlichingen. In 1773, the playwright Goethe drew loosely from Götz’s life for a drama about a charismatic and fearless knight who dies tragically, wounded and imprisoned, while exclaiming “Freedom – freedom!”. (The historical Götz died of old age.)

Black and white photo of an iron hand clenched in a fist

A 19th century photograph of the famous ‘second hand’ of Götz von Berlichingen with flexible finger joints.

Landesarchiv Baden-Württemberg/Wikimedia Commons., CC BY

Götz’s story has inspired visions of a bionic warrior ever since. Whether in the 18th century or the 21st, you can find mythical depictions of Götz standing defiant in the face of authority and clutching a sword in his iron hand – an impractical feat for his historical prosthesis. Until recently, scholars supposed all iron hands must have belonged to knights like Götz.

But my research reveals that many iron hands show no signs of having belonged to warriors, or perhaps even to . Cultural pioneers, many of whom are known only from the artifacts they left behind, drew on stylish trends that prized clever mechanical devices, like the miniature clockwork galleon displayed today at the British museum. In a society that coveted ingenious objects blurring the boundaries between art and nature, amputees used iron hands to defy negative stereotypes depicting them as pitiable. Surgeons took note of these devices, praising them in their treatises. Iron hands spoke a material language contemporaries understood.

Before the modern body of replaceable parts could exist, the body had to be reimagined as something humans could mold. But this reimagining required the efforts of more than just surgeons. It also took the collaboration of amputees and the artisans who helped construct their new limbs.The Conversation

Heidi Hausse, Assistant Professor of History, Auburn University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Modern surgery began with saws and iron hands – how amputation transformed the body in the Renaissance appeared first on .com

The Conversation

Halloween candy binges can overload your gut microbiome – a gut doctor explains how to minimize spooking your helpful bacteria

Published

on

theconversation.com – Christopher Damman, Associate Professor of Gastroenterology, School of Medicine, University of Washington – 2024-10-23 07:41:00

It’s probably best to enjoy your Halloween spoils in moderation.

Jupiterimages/The Image Bank via Getty Images

Christopher Damman, University of Washington

Each October, as the days shorten and the grows crisp, millions of Americans prepare for the beloved – and often sugar-fueled – tradition of Halloween. From jack-o’-lanterns glowing on porches to costumes ranging from the whimsical to the gory, Halloween is a time of playful scares, childhood memories and, of course, candy.

But as the wrappers pile up and the sugar rush hits, there’s something far more sinister beneath the surface: the negative effects of candy on your gut .

Sugar and other ingredients in Halloween treats can cast a sickly spell on the trillions of microorganisms that reside in your gut, collectively known as the gut microbiome. As a gastroenterologist and gut microbiome researcher at the University of Washington School of Medicine, I have dedicated my career to decoding the cipher of how food affects this microbial community within your gut.

While no candy is truly healthy, some options are better for your gut than others. And there are ways you can wake your gut from its sugar “spell” after holiday indulgence.

Gut-busting treats

What does all this candy do to your gut?

In a healthy state, your gut microbiome acts like a microbial factory. It digests nutrients your body can’t – such as fiber and colorful, health-conferring plant compounds called polyphenols – and produces important molecules called metabolites that protect against infection and brain health. It also regulates metabolism, or the transformation of food into useful components that power and grow cells.

A balanced diet keeps your gut’s microbial cauldron churning smoothly. But the concentrated sugar, saturated fat and additives in candy can throw things into disarray by feeding inflammatory microbes that weaken your gut barrier – the protective lining that separates your microbiome from the rest of the body.

Once the gut barrier is breached, even friendly microbes can stir up inflammation, causing health issues ranging from overweight to obesity, infections to autoimmune disease, and mild cognitive impairment to Alzheimer’s.

The food you eat shapes your gut microbes, which in turn shape your overall health.

Sugar and inflammation impair your microbiome’s ability to digest food and regulate metabolism. Instead of producing healthy byproducts – such as butyrate from fiber and urolithin A from polyphenols – candy lacking these nutrients may trick your system into storing more fat, providing less energy for your muscles and brain.

Too much candy can also affect your immune system. A healthy gut microbiome helps your immune system distinguish between friend and foe, reducing the risk of infections and autoimmune disorders. Sugar and inflammation undermine the microbiome’s role in training the immune system to distinguish between harmful invaders and harmless substances. Without a carefully calibrated immune system, your body may not effectively clear infections or may strongly react to its own cells.

Neurologically, excess sweets can also affect the gut-brain axis, the two-way communication between the gut and brain. A healthy microbiome normally produces neurotransmitters and metabolites, such as serotonin and butyrate, that influence mood and cognitive performance. Sugar and inflammation adversely affects the microbiome’s role in mental health and cognitive function, contributing to depression, anxiety and memory troubles.

The candy conundrum

Not all Halloween treats are created equal, especially when it to their nutritional value and effects on gut health. Sugar-coated nuts and fruit such as honey-roasted almonds and candy apples rank among the top, offering whole food just beneath the sugary coating. Packed with fiber and polyphenols, they help support gut health and healthy metabolism.

On the opposite end of the spectrum are chewy treats such as candy corn, Skittles, Starbursts and Twizzlers. These sugar-laden confections are mostly made of high fructose corn syrup, saturated fat and additives. They can increase the unsavory bacterial species in your gut and to inflammation, making them one of the least healthy Halloween choices.

Chocolate-based candies, however, stand out as a more microbiome-friendly option. While varieties such as Twix, Three Musketeers and Milky Way contain only a small amount of chocolate, pure chocolate bars – especially dark chocolate – are rich in fiber and polyphenols. In moderation, dark chocolate with at least 80% to 85% cacao may even benefit your gut microbiome and mood by encouraging beneficial bacterial species to grow.

Two green apples on a stick, coated in caramel and dusted with pecans.

Candy apples usually a serving of fruit and nuts.

Ryan Benyi Photography/Connect Images via Getty Images

Chocolates with whole nuts, such as almonds or peanuts, offer a boost of fiber, protein and omega-3 fats, making them a healthier choice. Dark chocolate with nuts is best. But when sorting through Halloween treats, Peanut M&Ms, 100 Grands and Almond Joys may be better options over Rolos, Krackels and Crunches. Even candies with processed nuts, such as Reese’s Peanut Butter Cups and Butterfingers, retain small amounts of fiber and protein, making them preferable to nut-free options.

At the bottom of the list, along with chewy sugar candies, are pure sugar candies such as lollipops, Jolly Ranchers, gummies and Smarties. These sweets lack nutritional value, and their high sugar content can contribute to the growth of unhealthy bacteria in your gut microbiome.

In the end, all candies are high in sugar, which can be harmful when consumed in large quantities. Moderation and an otherwise balanced diet is key to enjoying Halloween treats.

Rebalancing after indulgence

If the microbiome is critical for health, and candy can disrupt its balance, how can you restore gut health after Halloween?

One simple strategy is focusing on the four F’s of food: fiber, phytochemicals, unsaturated fats and fermented foods. These food components can help support gut health.

Fiber-rich foods such as whole grains, nuts, seeds, beans, fruits and vegetables regulate digestion and nourish beneficial gut bacteria.

Partially unwrapped chocolate bar

Dark chocolate is a treat that may offer some health benefits.

Wachiwit/iStock via Getty Images Plus

Polyphenol-rich foods such as dark chocolate, berries, red grapes, green tea and extra virgin olive oil help reduce inflammation and encourage the growth of healthy gut bacteria.

Unsaturated fats such as omega-3 fats, walnuts, chia seeds, flaxseed, avocados and fatty fish such as salmon can also support a healthy microbiome.

Fermented foods such as sauerkraut, kimchi, yogurt, kefir and miso help replenish beneficial bacteria and restore gut balance.

To make tracking your diet easier, consider using a food calculator to measure how well your meals align with the four F’s and microbiome friendly options. Like a virtual “spellbook,” an online tool can help ensure your food choices support your gut health and ward off the effects of sugar overload.

As my daughters often remind me, it’s perfectly fine to indulge every now and then in a few tricks and treats. But remember, moderation is key. With a balanced diet, you’ll keep your gut healthy and strong long after the Halloween season ends.The Conversation

Christopher Damman, Associate Professor of Gastroenterology, School of Medicine, University of Washington

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Halloween candy binges can overload your gut microbiome – a gut doctor explains how to minimize spooking your helpful bacteria appeared first on .com

Continue Reading

The Conversation

Both Harris and Trump have records on space policy − an international affairs expert examines where they differ when it comes to the final frontier

Published

on

theconversation.com G. Roberts, Postdoctoral Fellow in International Affiars, Georgia Institute of Technology – 2024-10-23 07:43:00

Neither candidate has talked much about policy on the campaign trail, but both have to consider.

Anton Petrus/Moment via Getty Images

Thomas G. Roberts, Georgia Institute of Technology

The next president of the United States could be the first in that office to accept a phone call from the Moon and hear a woman’s voice on the line. To do so, they’ll first need to make a series of strategic space policy decisions. They’ll also need a little luck.

Enormous government investment supports outer space activities, so the U.S. president has an outsize role in shaping space policy during their time in office.

Past presidents have leveraged this power to accelerate U.S. leadership in space and boost their presidential brand along the way. Presidential advocacy has helped the U.S. astronauts on the surface of the Moon, establish lasting international partnerships with civil space agencies abroad and led to many other important space milestones.

But most presidential candidates refrain from discussing space policy on the campaign trail in meaningful detail, leaving voters in the dark on their visions for the final frontier.

For many candidates, getting into the weeds of their space policy plans may be more trouble than it’s worth. For one, not every president even gets the for meaningful and memorable space policy -making, since space missions can operate on decades-long timelines. And in past elections, those who do show for space initiatives often face criticism from their opponents for their high price tags.

But the 2024 election is different. Both candidates have executive records in space policy, a rare treat for space enthusiasts casting their votes this November.

As a researcher who studies international affairs in outer space, I am interested in how those records interface with the strategic and sustainable use of that domain. A closer look shows that former and Vice President Kamala Harris have used their positions to consistently prioritize U.S. leadership in space, but they have done so with noticeably different styles and results.

Trump’s space policy record

As president, Trump established a record of meaningful and lasting space policy decisions, but did so while attracting more attention to his administration’s space activities than his predecessors. He regularly took personal credit for ideas and accomplishments that predated his time in office.

The former president oversaw the establishment of the U.S. Space Force and the reestablishment of the U.S. Space Command, as well as the National Space Council. These organizations support the development and operation of military space technologies, defend national security satellites in future conflicts and coordinate between federal agencies working in the space domain.

A commander in military uniform waves a black flag with the emblem of the US Space Force (an arrow pointing up in front of a sphere representing the Earth).

While president, Donald Trump oversaw the creation of the U.S. Space Force.

AP Photo/Alex Brandon

He also had the most productive record of space policy directives in recent history. These policy directives clarify the U.S. government’s goals in space, how it should both support and rely on the commercial space sector, track objects in Earth’s orbit and protect satellites from cyber threats.

He has called his advocacy for the creation of the Space Force one of his proudest achievements of his term. However, this advocacy contributed to polarized support for the new branch. This polarization broke the more common pattern of bipartisan public support for space programming.

Like many presidents, not all of Trump’s visions for space were realized. He successfully redirected NASA’s key human spaceflight destination from Mars back to the Moon. But his explicit goal of astronauts reaching the lunar surface by 2024 was not realistic, given his budget proposal for the agency.

Should he be elected again, the former president may wish to accelerate NASA’s Moon plans by furthering investment in the agency’s Artemis program, which houses its lunar initiatives.

He may frame the initiative as a new space race against China.

Harris’ space policy record

The Biden administration has continued to support Trump-era initiatives, resisting the temptation to undo or cancel past proposals. Its legacy in space is noticeably smaller.

As the chair of the National Space Council, Harris has set U.S. space policy priorities and represented the United States on the global stage.

A group of people gathered around a large table, with Kamala Harris standing at a podium at the front next to a screen that says 'National Space Council.'

As vice president, Harris has chaired the National Space Council.

NASA/Joel Kowsky, CC BY-NC-ND

Notably, the Trump administration kept this position that the president can alter at will assigned to the vice president, a precedent the Biden administration upheld.

In this role, Harris led the United States’ commitment to refrain from testing weapons in space that produce dangerous, long-lasting space debris. This decision marks an achievement for the U.S. in keeping space operations sustainable and setting an example for others in the international space community.

Like some Trump administration space policy priorities, not all of Harris’ proposals found footing in Washington.

The council’s plan to establish a framework for comprehensively regulating commercial space activities in the U.S., for example, stalled in Congress.

If enacted, these new regulations would have ensured that future space activities, such as private companies operating on the Moon or transporting tourists to orbit and back, pass critical safety checks.

Should she be elected, Harris may choose to continue her efforts to shape responsible norms of behavior in space and organize oversight over the space industry.

Alternatively, she could cede the portfolio to her own vice president, Minnesota Gov. Tim Walz, who has virtually no track record on space policy issues.

Stability in major space policy decisions

Despite the two candidates’ vastly different platforms, voters can expect stability in U.S. space policy as a result of this year’s election.

Given their past leadership, it is unlikely that either candidate will seek to dramatically alter the long-term missions the largest government space organizations have underway during the upcoming presidential term. And neither is likely to undercut their predecessors’ accomplishments.The Conversation

Thomas G. Roberts, Postdoctoral Fellow in International Affiars, Georgia Institute of Technology

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Both Harris and Trump have records on space policy − an international affairs expert examines where they differ when it comes to the final frontier appeared first on .com

Continue Reading

The Conversation

Women are at a higher risk of dying from heart disease − in part because doctors don’t take major sex and gender differences into account

Published

on

theconversation.com – Amy Huebschmann, Professor of Medicine, of Colorado Anschutz Medical Campus – 2024-10-22 07:45:00

Rates of heart disease and cardiac in women are often underestimated.

eternalcreative/iStock via Getty Images

Amy Huebschmann, University of Colorado Anschutz Medical Campus and Judith Regensteiner, University of Colorado Anschutz Medical Campus

A simple difference in the genetic code – two X chromosomes versus one X chromosome and one Y chromosome – can to major differences in heart disease. It turns out that these genetic differences influence more than just sex organs and sex assigned at birth – they fundamentally alter the way cardiovascular disease develops and presents.

While sex influences the mechanisms behind how cardiovascular disease develops, gender plays a role in how care providers recognize and manage it. Sex refers to biological characteristics such as genetics, hormones, anatomy and physiology, while gender refers to social, psychological and cultural constructs. Women are more likely to die after a first heart attack or stroke than . Women are also more likely to have additional or different heart attack symptoms that go beyond chest pain, such as nausea, jaw pain, dizziness and fatigue. It is often difficult to fully disentangle the influences of sex on cardiovascular disease outcomes versus the influences of gender.

While women who haven’t entered menopause have a lower risk of cardiovascular disease than men, their cardiovascular risk accelerates dramatically after menopause. In addition, if a woman has Type 2 diabetes, her risk of heart attack accelerates to be equivalent to that of men, even if the woman with diabetes has not yet gone through menopause. Further data is needed to better understand differences in cardiovascular disease risk among nonbinary and transgender patients.

Despite these differences, one key thing is the same: Heart attack, stroke and other forms of cardiovascular disease are the leading cause of death for all people, regardless of sex or gender.

We are researchers who study women’s health and the way cardiovascular disease develops and presents differently in women and men. Our work has identified a crucial need to medical guidelines with more sex-specific approaches to diagnosis and treatment in order to improve health outcomes for all.

Gender differences in heart disease

The reasons behind sex and gender differences in cardiovascular disease are not completely known. Nor are the distinct biological effects of sex, such as hormonal and genetic factors, versus gender, such as social, cultural and psychological factors, clearly differentiated.

What researchers do know is that the accumulated evidence of what good heart care should look like for women compared with men has as many holes in it as Swiss cheese. Medical evidence for treating cardiovascular disease often comes from trials that excluded women, since women for the most part weren’t included in scientific research until the NIH Revitalization Act of 1993. For example, current guidelines to treat cardiovascular risk factors such as high blood pressure are based primarily on data from men. This is despite evidence that differences in the way that cardiovascular disease develops leads women to experience cardiovascular disease differently.

Clinician holding stethoscope against a patient's chest

Gender biases in health care influence the kind of tests and attention that women receive.

FG Trade Latin/E+ via Getty Images

In addition to sex differences, implicit gender biases among providers and gendered social norms among patients lead clinicians to underestimate the risk of cardiac events in women with men. These biases play a role in why women are more likely than men to die from cardiac events. For example, for patients with symptoms that are borderline for cardiovascular disease, clinicians tend to be more aggressive in ordering artery imaging for men than for women. One study linked this tendency to order less aggressive tests for women partly to a gender bias that men are more open than women to taking risks.

In a study of about 3,000 patients with a recent heart attack, women were less likely than men to think that their heart attack symptoms were due to a heart . Additionally, most women do not know that cardiovascular disease is the No. 1 cause of death among women. Overall, women’s misperceptions of their own risk may hold them back from getting a doctor to check out possible symptoms of a heart attack or stroke.

These issues are further exacerbated for women of color. Lack of access to health care and additional challenges drive health disparities among underrepresented racial and ethnic minority populations.

Sex difference in heart disease

Cardiovascular disease physically looks different for women and men, specifically in the plaque buildup on artery walls that contributes to illness.

Women have fewer cholesterol crystals and fewer calcium deposits in their artery plaque than men do. Physiological differences in the smallest blood vessels feeding the heart also play a role in cardiovascular outcomes.

Women are more likely than men to have cardiovascular disease that presents as multiple narrowed arteries that are not fully “clogged,” resulting in chest pain because blood flow can’t ratchet up enough to meet higher oxygen demands with exercise, much like a low-flow showerhead. When chest pain presents in this way, doctors call this condition ischemia and no obstructive coronary arteries. In comparison, men are more likely to have a “clogged” artery in a concentrated area that can be opened up with a stent or with cardiac bypass surgery. Options for multiple narrowed arteries have lagged behind treatment options for typical “clogged” arteries, which puts women at a disadvantage.

In addition, in the early stages of a heart attack, the levels of blood markers that indicate damage to the heart are lower in women than in men. This can lead to more missed diagnoses of coronary artery disease in women compared with men.

The reasons for these differences are not fully clear. Some potential factors include differences in artery plaque composition that make men’s plaque more likely to rupture or burst and women’s plaque more likely to erode. Women also have lower heart mass and smaller arteries than men even after taking body size into consideration.

Reducing sex disparities

Too often, women with symptoms of cardiovascular disease are sent away from doctor’s offices because of gender biases that “women don’t get heart disease.”

Considering how symptoms of cardiovascular disease vary by sex and gender could doctors better care for all patients.

One way that the rubber is meeting the road is with regard to better approaches to diagnosing heart attacks for women and men. Specifically, when diagnosing heart attacks, using sex-specific cutoffs for blood tests that measure heart damage – called high-sensitivity troponin tests – can improve their accuracy, decreasing missed diagnoses, or false negatives, in women while also decreasing overdiagnoses, or false positives, in men.

Our research laboratory’s leaders,collaborators and other internationally recognized research colleagues – some of whom partner with our Ludeman Family Center for Women’s Health Research on the University of Colorado Anschutz Medical Campus – will continue this important work to close this gap between the sexes in health care. Research in this field is critical to shine a light on ways clinicians can better address sex-specific symptoms and to bring forward more tailored treatments.

The Biden administration’s recent executive order to advance women’s health research is paving the way for research to go beyond just understanding what causes sex differences in cardiovascular disease. Developing and testing right-sized approaches to care for each patient can help achieve better health for all.The Conversation

Amy Huebschmann, Professor of Medicine, University of Colorado Anschutz Medical Campus and Judith Regensteiner, Professor of Medicine, University of Colorado Anschutz Medical Campus

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Read More

The post Women are at a higher risk of dying from heart disease − in part because doctors don’t take major sex and gender differences into account appeared first on .com

Continue Reading

Trending