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Your unique body odor could identify who you are and provide insights into your health – all from the touch of a hand

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Your unique body odor could identify who you are and provide insights into your health – all from the touch of a hand

The scent emitted from your hands could offer clues about who you are.
Siro Rodenas Cortes/Moment via Getty Images

Chantrell Frazier, Framingham State University; Kenneth G. Furton, Florida International University, and Vidia A. Gokool, Lawrence Livermore National Laboratory

From the aroma of fresh-cut grass to the smell of a loved one, you encounter scents in every part of your life. Not only are you constantly surrounded by odor, you’re also producing it. And it is so distinctive that it can be used to tell you apart from everyone around you.

Your scent is a complex product influenced by many factors, including your genetics. Researchers believe that a particular group of genes, the major histocompatibility complex, play a large role in scent production. These genes are involved in the body’s immune response and are believed to influence body odor by encoding the production of specific proteins and chemicals.

But your scent isn’t fixed once your body produces it. As sweat, oils and other secretions make it to the surface of your skin, microbes break down and transform these compounds, changing and adding to the odors that make up your scent. This scent medley emanates from your body and settles into the environments around you. And it can be used to track, locate or identify a particular person, as well as distinguish between healthy and unhealthy people.

We are researchers who specialize in studying human scent through the detection and characterization of gaseous chemicals called volatile organic compounds. These gases can relay an abundance of information for both forensic researchers and health care providers.

Human scent analysis breaks down body odor to its individual components.

Science of body odor

When you are near another person, you can feel their body heat without touching them. You may even be able to smell them without getting very close. The natural warmth of the human body creates a temperature differential with the air around it. You warm up the air nearest to you, while air that’s farther away remains cool, creating warm currents of air that surround your body.

Researchers believe that this plume of air helps disperse your scent by pushing the millions of skin cells you shed over the course of a day off your body and into the environment. These skin cells act as boats or rafts carrying glandular secretions and your resident microbes – a combination of ingredients that emit your scent – and depositing them in your surroundings.

Your scent is composed of the volatile organic compounds present in the gases emitted from your skin. These gases are the combination of sweat, oils and trace elements exuded from the glands in your skin. The primary components of your odor depend on internal factors such as your race, ethnicity, biological sex and other traits. Secondary components waver based on factors like stress, diet and illness. And tertiary components from external sources like perfumes and soaps build on top of your distinguishable odor profile.

Identity of scent

With so many factors influencing the scent of any given person, your body odor can be used as an identifying feature. Scent detection canines searching for a suspect can look past all the other odors they encounter to follow a scent trail left behind by the person they are pursuing. This practice relies on the assumption that each person’s scent is distinct enough that it can be distinguished from other people’s.

Researchers have been studying the discriminating potential of human scent for over three decades. A 1988 experiment demonstrated that a dog could distinguish identical twins living apart and exposed to different environmental conditions by their scent alone. This is a feat that could not be accomplished using DNA evidence, as identical twins share the same genetic code.

The field of human scent analysis has expanded over the years to further study the composition of human scent and how it can be used as a form of forensic evidence. Researchers have seen differences in human odor composition that can be classified based on sex, gender, race and ethnicity. Our research team’s 2017 study of 105 participants found that specific combinations of 15 volatile organic compounds collected from people’s hands could distinguish between race and ethnicity with an accuracy of 72% for whites, 82% for East Asians and 67% for Hispanics. Based on a combination of 13 compounds, participants could be distinguished as male or female with an overall 80% accuracy.

Researchers have trained dogs to sniff out COVID-19 infections.

Researchers are also producing models to predict the characteristics of a person based on their scent. From a sample pool of 30 women and 30 men, our team built a machine learning model that could predict a person’s biological sex with 96% accuracy based on hand odor.

Scent of health

Odor research continues to provide insights into illnesses. Well-known examples of using scent in medical assessments include seizure and diabetic alert canines. These dogs can give their handlers time to prepare for an impending seizure or notify them when they need to adjust their blood glucose levels.

While these canines often work with a single patient known to have a condition that requires close monitoring, medical detection dogs can also indicate whether someone is ill. For example, researchers have shown that dogs can be trained to detect cancer in people. Canines have also been trained to detect COVID-19 infections at a 90% accuracy rate.

Similarly, our research team found that a laboratory analysis of hand odor samples could discriminate between people who are COVID-19 positive or negative with 75% accuracy.

Forensics of scent

Human scent offers a noninvasive method to collect samples. While direct contact with a surface like touching a doorknob or wearing a sweater provides a clear route for your scent to transfer to that surface, simply standing still will also transfer your odor into the surrounding area.

Although human scent has the potential to be a critical form of forensic evidence, it is still a developing field. Imagine a law enforcement officer collecting a scent sample from a crime scene in hopes that it may match with a suspect.

Further research into human scent analysis can help fill the gaps in our understanding of the individuality of human scent and how to apply this information in forensic and biomedical labs.The Conversation

Chantrell Frazier, Assistant Professor of Chemistry and Food Science, Framingham State University; Kenneth G. Furton, Professor of Chemistry and Biochemistry, Florida International University, and Vidia A. Gokool, Postdoctoral Researcher, Lawrence Livermore National Laboratory

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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I’m a neuroscientist who taught rats to drive − their joy suggests how anticipating fun can enrich human life

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theconversation.com – Kelly Lambert, Professor of Behavioral Neuroscience, University of Richmond – 2024-11-11 07:21:00

Rats will choose to take a longer route if it means they get to enjoy the ride to their destination.
Kelly Lambert, CC BY-ND

Kelly Lambert, University of Richmond

We crafted our first rodent car from a plastic cereal container. After trial and error, my colleagues and I found that rats could learn to drive forward by grasping a small wire that acted like a gas pedal. Before long, they were steering with surprising precision to reach a Froot Loop treat.

As expected, rats housed in enriched environments – complete with toys, space and companions – learned to drive faster than those in standard cages. This finding supported the idea that complex environments enhance neuroplasticity: the brain’s ability to change across the lifespan in response to environmental demands.

After we published our research, the story of driving rats went viral in the media. The project continues in my lab with new, improved rat-operated vehicles, or ROVs, designed by robotics professor John McManus and his students. These upgraded electrical ROVs – featuring rat-proof wiring, indestructible tires and ergonomic driving levers – are akin to a rodent version of Tesla’s Cybertruck.

As a neuroscientist who advocates for housing and testing laboratory animals in natural habitats, I’ve found it amusing to see how far we’ve strayed from my lab practices with this project. Rats typically prefer dirt, sticks and rocks over plastic objects. Now, we had them driving cars.

But humans didn’t evolve to drive either. Although our ancient ancestors didn’t have cars, they had flexible brains that enabled them to acquire new skills – fire, language, stone tools and agriculture. And some time after the invention of the wheel, humans made cars.

Although cars made for rats are far from anything they would encounter in the wild, we believed that driving represented an interesting way to study how rodents acquire new skills. Unexpectedly, we found that the rats had an intense motivation for their driving training, often jumping into the car and revving the “lever engine” before their vehicle hit the road. Why was that?

Some rats training to drive press a lever before their car is placed on the track, as if they’re eagerly anticipating the ride ahead.

The new destination of joy

Concepts from introductory psychology textbooks took on a new, hands-on dimension in our rodent driving laboratory. Building on foundational learning approaches such as operant conditioning, which reinforces targeted behavior through strategic incentives, we trained the rats step-by-step in their driver’s ed programs.

Initially, they learned basic movements, such as climbing into the car and pressing a lever. But with practice, these simple actions evolved into more complex behaviors, such as steering the car toward a specific destination.

The rats also taught me something profound one morning during the pandemic.

It was the summer of 2020, a period marked by emotional isolation for almost everyone on the planet, even laboratory rats. When I walked into the lab, I noticed something unusual: The three driving-trained rats eagerly ran to the side of the cage, jumping up like my dog does when asked if he wants to take a walk.

Had the rats always done this and I just hadn’t noticed? Were they just eager for a Froot Loop, or anticipating the drive itself? Whatever the case, they appeared to be feeling something positive – perhaps excitement and anticipation.

Behaviors associated with positive experiences are associated with joy in humans, but what about rats? Was I seeing something akin to joy in a rat? Maybe so, considering that neuroscience research is increasingly suggesting that joy and positive emotions play a critical role in the health of both human and nonhuman animals.

With that, my team and I shifted focus from topics such as how chronic stress influences brains to how positive events – and anticipation for these events – shape neural functions.

Two rats in a 'car' made of an open glass box and four wheels
Rats hitting the road in their custom-made cruisers.
Kelly Lambert, CC BY-ND

Working with postdoctoral fellow Kitty Hartvigsen, I designed a new protocol that used waiting periods to ramp up anticipation before a positive event. Bringing Pavlovian conditioning into the mix, rats had to wait 15 minutes after a Lego block was placed in their cage before they received a Froot Loop. They also had to wait in their transport cage for a few minutes before entering Rat Park, their play area. We also added challenges, such as making them shell sunflower seeds before eating.

This became our Wait For It research program. We dubbed this new line of study UPERs – unpredictable positive experience responses – where rats were trained to wait for rewards. In contrast, control rats received their rewards immediately. After about a month of training, we expose the rats to different tests to determine how waiting for positive experiences affects how they learn and behave. We’re currently peering into their brains to map the neural footprint of extended positive experiences.

Preliminary results suggest that rats required to wait for their rewards show signs of shifting from a pessimistic cognitive style to an optimistic one in a test designed to measure rodent optimism. They performed better on cognitive tasks and were bolder in their problem-solving strategies. We linked this program to our lab’s broader interest in behaviorceuticals, a term I coined to suggest that experiences can alter brain chemistry similarly to pharmaceuticals.

This research provides further support of how anticipation can reinforce behavior. Previous work with lab rats has shown that rats pressing a bar for cocaine – a stimulant that increases dopamine activation – already experience a surge of dopamine as they anticipate a dose of cocaine.

The tale of rat tails

It wasn’t just the effects of anticipation on rat behavior that caught our attention. One day, a student noticed something strange: One of the rats in the group trained to expect positive experiences had its tail straight up with a crook at the end, resembling the handle of an old-fashioned umbrella.

I had never seen this in my decades of working with rats. Reviewing the video footage, we found that the rats trained to anticipate positive experiences were more likely to hold their tails high than untrained rats. But what, exactly, did this mean?

Rat beside a small house, its tail curved up like an umbrella handle
Rat tails can signal how they’re feeling.
Kelly Lambert, CC BY-SA

Curious, I posted a picture of the behavior on social media. Fellow neuroscientists identified this as a gentler form of what’s called Straub tail, typically seen in rats given the opioid morphine. This S-shaped curl is also linked to dopamine. When dopamine is blocked, the Straub tail behavior subsides.

Natural forms of opiates and dopamine – key players in brain pathways that diminish pain and enhance reward – seem to be telltale ingredients of the elevated tails in our anticipation training program. Observing tail posture in rats adds a new layer to our understanding of rat emotional expression, reminding us that emotions are expressed throughout the entire body.

While we can’t directly ask rats whether they like to drive, we devised a behavioral test to assess their motivation to drive. This time, instead of only giving rats the option of driving to the Froot Loop Tree, they could also make a shorter journey on foot – or paw, in this case.

Surprisingly, two of the three rats chose to take the less efficient path of turning away from the reward and running to the car to drive to their Froot Loop destination. This response suggests that the rats enjoy both the journey and the rewarding destination.

Rat lessons on enjoying the journey

We’re not the only team investigating positive emotions in animals.

Neuroscientist Jaak Panksepp famously tickled rats, demonstrating their capacity for joy.

Research has also shown that desirable low-stress rat environments retune their brains’ reward circuits, such as the nucleus accumbens. When animals are housed in their favored environments, the area of the nucleus accumbens that responds to appetitive experiences expands. Alternatively, when rats are housed in stressful contexts, the fear-generating zones of their nucleus accumbens expand. It is as if the brain is a piano the environment can tune.

Neuroscientist Curt Richter also made the case for rats having hope. In a study that wouldn’t be permitted today, rats swam in glass cylinders filled with water, eventually drowning from exhaustion if they weren’t rescued. Lab rats frequently handled by humans swam for hours to days. Wild rats gave up after just a few minutes. If the wild rats were briefly rescued, however, their survival time extended dramatically, sometimes by days. It seemed that being rescued gave the rats hope and spurred them on.

The driving rats project has opened new and unexpected doors in my behavioral neuroscience research lab. While it’s vital to study negative emotions such as fear and stress, positive experiences also shape the brain in significant ways.

As animals – human or otherwise – navigate the unpredictability of life, anticipating positive experiences helps drive a persistence to keep searching for life’s rewards. In a world of immediate gratification, these rats offer insights into the neural principles guiding everyday behavior. Rather than pushing buttons for instant rewards, they remind us that planning, anticipating and enjoying the ride may be key to a healthy brain. That’s a lesson my lab rats have taught me well.The Conversation

Kelly Lambert, Professor of Behavioral Neuroscience, University of Richmond

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Missing link to Snowball Earth history emerges from some unusual rocks on Colorado’s Pikes Peak

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theconversation.com – Liam Courtney-Davies, Postdoctoral Research Associate in Geological Sciences, University of Colorado Boulder – 2024-11-11 14:03:00

Rocks can hold clues to history dating back hundreds of millions of years.
Christine S. Siddoway

Liam Courtney-Davies, University of Colorado Boulder; Christine Siddoway, Colorado College, and Rebecca Flowers, University of Colorado Boulder

Around 700 million years ago, the Earth cooled so much that scientists believe massive ice sheets encased the entire planet like a giant snowball. This global deep freeze, known as Snowball Earth, endured for tens of millions of years.

Yet, miraculously, early life not only held on, but thrived. When the ice melted and the ground thawed, complex multicellular life emerged, eventually leading to life-forms we recognize today.

The Snowball Earth hypothesis has been largely based on evidence from sedimentary rocks exposed in areas that once were along coastlines and shallow seas, as well as climate modeling. Physical evidence that ice sheets covered the interior of continents in warm equatorial regions had eluded scientists – until now.

In new research published in the Proceedings of the National Academy of Sciences, our team of geologists describes the missing link, found in an unusual pebbly sandstone encapsulated within the granite that forms Colorado’s Pikes Peak.

An illustration of an icy earth viewed from space
Earth iced over during the Cryogenian Period, but life on the planet survived.
NASA illustration

Solving a Snowball Earth mystery on a mountain

Pikes Peak, originally named Tavá Kaa-vi by the Ute people, lends its ancestral name, Tava, to these notable rocks. They are composed of solidified sand injectites, which formed in a similar manner to a medical injection when sand-rich fluid was forced into underlying rock.

A possible explanation for what created these enigmatic sandstones is the immense pressure of an overlying Snowball Earth ice sheet forcing sediment mixed with meltwater into weakened rock below.

A hand holds a rock with dark seams through it and other colors.
Dark red to purple bands of Tava sandstone dissect pink and white granite. The Tava is also cross-cut by silvery-gray veins of iron oxide.
Liam Courtney-Davies

An obstacle for testing this idea, however, has been the lack of an age for the rocks to reveal when the right geological circumstances existed for sand injection.

We found a way to solve that mystery, using veins of iron found alongside the Tava injectites, near Pikes Peak and elsewhere in Colorado.

A cliff side showing a long strip of lighter color Tava cutting through Pikes Peak Granite. The injectite here is 5 meters tall
A 5-meter-tall, almost vertical Tava dike is evident in this section of Pikes Peak granite.
Liam Courtney-Davies

Iron minerals contain very low amounts of naturally occurring radioactive elements, including uranium, which slowly decays to the element lead at a known rate. Recent advancements in laser-based radiometric dating allowed us to measure the ratio of uranium to lead isotopes in the iron oxide mineral hematite to reveal how long ago the individual crystals formed.

The iron veins appear to have formed both before and after the sand was injected into the Colorado bedrock: We found veins of hematite and quartz that both cut through Tava dikes and were crosscut by Tava dikes. That allowed us to figure out an age bracket for the sand injectites, which must have formed between 690 million and 660 million years ago.

So, what happened?

The time frame means these sandstones formed during the Cryogenian Period, from 720 million to 635 million years ago. The name is derived from “cold birth” in ancient Greek and is synonymous with climate upheaval and disruption of life on our planet – including Snowball Earth.

While the triggers for the extreme cold at that time are debated, prevailing theories involve changes in tectonic plate activity, including the release of particles into the atmosphere that reflected sunlight away from Earth. Eventually, a buildup of carbon dioxide from volcanic outgassing may have warmed the planet again.

University of Exeter professor Timothy Lenton explains why the Earth was able to freeze over.

The Tava found on Pikes Peak would have formed close to the equator within the heart of an ancient continent named Laurentia, which gradually over time and long tectonic cycles moved into its current northerly position in North America today.

The origin of Tava rocks has been debated for over 125 years, but the new technology allowed us to conclusively link them to the Cryogenian Snowball Earth period for the first time.

The scenario we envision for how the sand injection happened looks something like this:

A giant ice sheet with areas of geothermal heating at its base produced meltwater, which mixed with quartz-rich sediment below. The weight of the ice sheet created immense pressures that forced this sandy fluid into bedrock that had already been weakened over millions of years. Similar to fracking for natural gas or oil today, the pressure cracked the rocks and pushed the sandy meltwater in, eventually creating the injectites we see today.

Clues to another geologic puzzle

Not only do the new findings further cement the global Snowball Earth hypothesis, but the presence of Tava injectites within weak, fractured rocks once overridden by ice sheets provides clues about other geologic phenomena.

Time gaps in the rock record created through erosion and referred to as unconformities can be seen today across the United States, most famously at the Grand Canyon, where in places, over a billion years of time is missing. Unconformities occur when a sustained period of erosion removes and prevents newer layers of rock from forming, leaving an unconformable contact.

Unconformity in the Grand Canyon is evident here where horizontal layers of 500-million-year-old rock sit on top of a mass of 1,800-million-year-old rocks. The unconformity, or ‘time gap,’ demonstrates that years of history are missing.
Mike Norton via Wikimedia, CC BY-SA

Our results support that a Great Unconformity near Pikes Peak must have been formed prior to Cryogenian Snowball Earth. That’s at odds with hypotheses that attribute the formation of the Great Unconformity to large-scale erosion by Snowball Earth ice sheets themselves.

We hope the secrets of these elusive Cryogenian rocks in Colorado will lead to the discovery of further terrestrial records of Snowball Earth. Such findings can help develop a clearer picture of our planet during climate extremes and the processes that led to the habitable planet we live on today.The Conversation

Liam Courtney-Davies, Postdoctoral Research Associate in Geological Sciences, University of Colorado Boulder; Christine Siddoway, Professor of Geology, Colorado College, and Rebecca Flowers, Professor of Geological Sciences, University of Colorado Boulder

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Compassion amid chaos − how one of America’s greatest poets became a lifeline for wounded soldiers

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theconversation.com – Richard Gunderman, Chancellor’s Professor of Medicine, Liberal Arts, and Philanthropy, Indiana University – 2024-11-08 07:39:00

Richard Gunderman, Indiana University

With over 40 armed conflicts now taking place around the world, the costs of warfare are immense and continue to mount with each passing day.

Russia’s war on Ukraine is estimated to have resulted in more than 600,000 Russian casualties, with estimates of total dead and injured on both sides as high as 1 million. The war between Israel and Hamas has resulted in about 140,000 Palestinian and 10,000 Israeli casualties, and there have been at least 50,000 casualties in the ongoing Sudanese Civil War. Closer to home, the newly married son of a colleague of mine suffered grievous injuries and lost all four limbs in an explosion while serving in the Middle East.

The loss of life and limb, violations of human rights, destruction of personal property and damage to infrastructure such as power stations, hospitals and roads render such costs essentially incalculable, at least in monetary terms.

Yet war also opens up opportunities to care for the injured, displaced and forgotten. As someone who studies and writes about the intersection of medicine and the humanities, I often find myself returning to the American poet Walt Whitman.

To appreciate the act of offering support and comfort for the victims of war, there are few better sources of inspiration than Whitman, who spent more than three years volunteering his time and energies during the U.S. Civil War.

Compelled to help

Walt Whitman is considered one of the greatest poets in American history. Born the second of nine children in straitened circumstances in New York in 1819, he left school at age 11 to help support his family, working in a variety of jobs, including typesetting, teaching and newspaper publishing.

In 1855, he self-published his greatest work of poetry, “Leaves of Grass,” written in free verse and opening with the poem later known as “Song of Myself.” The work’s fans included Ralph Waldo Emerson, who wrote to Whitman, in a letter praising the poet, “I greet you at the beginning of a great career.”

Black-and-white portrait of bearded man seated, wearing a floppy hat, with his hands in his jacket pockets.

A portrait of Walt Whitman from 1863, when the U.S. was embroiled in civil war.

Smith Collection/Gado via Getty Images

Yet fame and fortune were slow to wend their way to Whitman, and he continued to work in the newspaper trade. With the onset of the Civil War, Whitman’s brother enlisted, and when Whitman saw his brother named among wounded soldiers, he traveled to Virginia to find him.

He eventually discovered that his brother had suffered only a minor wound. Yet during the search, Whitman encountered scores of wounded soldiers and piles of amputated limbs, which moved him to help in some way.

He secured a job in Washington, D.C., as an army paymaster’s clerk and began volunteering in the city’s military hospitals, making, by his estimate, over 600 visits, sometimes overnight, to as many as 100,000 soldiers.

Dispenser of treats, transcriber of letters

Why would perhaps America’s greatest poet voluntarily devote the better part of over three years of his life to visiting places replete with mutilation, agony and sorrow?

Lacking formal training in medicine or nursing, Whitman nonetheless felt that he had something important to offer.

“I found it was in the simple matter of personal presence, and emanating ordinary cheer and magnetism, that I succeeded and helped more than by medical nursing, or delicacies, or gifts of money, or anything else,” he wrote in “Memoranda During the War.”

Whitman managed to bring more tangible gifts as well: “Blackberries, peaches, lemons and sugar, wines, all kinds of preserves, pickles, brandy, milk, shirts and all articles of underclothing, tobacco, tea, and handkerchiefs.”

He procured these items using his own meager funds and by soliciting donations, providing others their own opportunities to give.

Consider a specific case, that of a young soldier from Massachusetts suffering from respiratory and gastrointestinal ailments.

Of him, Whitman wrote, “His heart was broken. He felt the struggle to keep up any longer to be useless. God, the world, humanity, all had abandoned him. It would feel so good to shut his eyes forever on the cruel things around him and toward him.”

Yet Whitman took his place beside him, gave him some money so that he could buy milk, and wrote a letter for him to his sister. “Trifling as it was, he was overcome and began to cry. He has told me since that this little visit, at that hour, just saved him – a day more, and it would have been perhaps too late.”

Along with all the other gifts in his haversack, Whitman “always gave paper, envelopes, and stamps” so soldiers could write to loved ones back home. Many times, he wrote their letters himself, in his own hand, often signing below their name, “Written by Walt Whitman, a friend.”

Of the letters, he noted:

“Many sick and wounded soldiers have not written home to parents, brothers, sisters, and even wives, for one reason or another, for a long time. Some are poor writers, some cannot get paper and envelopes; many have an aversion to writing because they dread to worry the folks at home – the facts about them are so sad to tell. I always encourage the men to write, and promptly write for them.”

It is remarkable to think of one of the greatest artists of the English language sitting by the bedside of so many sick and wounded soldiers, helping them compose letters to family and friends far away, sometimes simply transcribing what they said, and other times capturing what they wanted to say or what needed to be said.

He was tending not only to the soldiers before him, but also to loved ones sick with worry, hundreds of miles away.

Becoming conduits of compassion

Whitman’s dedicated service offers deep and enduring lessons for people around the world today.

A lined page featuring handwritten cursive.

The second page of a letter Walt Whitman wrote on behalf of Union soldier Robert N. Jabo, who was dying of tuberculosis. It was signed, ‘Written by Walt Whitman, a friend.’

U.S. National Archives

For one thing, the toll of war cannot simply be counted up in numbers of lives lost or billions of dollars of damage incurred.

Behind every number is a human story. Every wounded or dead soldier is someone’s son or daughter, sister or brother, husband or wife, or mother or father. Every civilian casualty is someone’s friend, neighbor and fellow citizen.

Whitman didn’t use his poetic powers just to help share the stories of wounded soldiers with their loved ones back home. He also mined his experiences by their bedside to compose literary masterpieces such as “The Wound-Dresser” and “Come Up from the Fields Father.”

As violence permeates the globe, it’s easy to look away, or become numb to headlines and images of death and despair. But confronting this suffering head on – through an act as simple as extending a hand, a voice or an ear – is an act of courage in and of itself.

True, it may not stop or win a war. Yet this sort of attention is a form of generosity and a conduit to healing – a way, as Whitman put it in a letter to his brother, “to have our feelings so thoroughly and permanently absorbed, to the very roots, by these huge swarms of dear, wounded, sick, and dying boys.”The Conversation

Richard Gunderman, Chancellor’s Professor of Medicine, Liberal Arts, and Philanthropy, Indiana University

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