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Lifecycle of a research grant – behind the scenes of the system that funds science

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theconversation.com – Kelly S. Mix, Associate Dean for Research, Innovation, and Partnerships in the College of Education, University of Maryland – 2025-05-22 07:44:00


Science funding involves a rigorous, multi-stage process ensuring responsible use of grants. Researchers submit applications responding to specific requests for proposals (RFPs) from agencies like NIH and NSF, outlining their project’s need and research plan. Applications undergo triage for compliance, then a thorough merit review by anonymous content experts who evaluate innovation, methodology, and impact. Reviewers disclose conflicts of interest and participate in confidential panel discussions to reach fair scores. Funding decisions rely on these evaluations, with program staff making final calls. Universities enforce strict spending rules, monitoring expenses via approvals, receipts, and audits to maintain integrity and future funding access.

Without grants for salaries, supplies and more, many research labs would be empty.
Solskin/DigitalVision via Getty Images

Kelly S. Mix, University of Maryland

Science funding is a hot topic these days and people have questions about how grants work. Who decides whether a researcher will receive funds? What’s the decision-making process? How is the money spent once a grant proposal has been approved?

As a veteran academic researcher, department chairperson and associate dean for research, I have seen this process play out from multiple perspectives – as a grant recipient, grant reviewer and university administrator.

Research organizations and major federal funders, including the National Institutes of Health, the National Science Foundation and the Defense Advanced Research Projects Agency (DARPA), all rely on careful systems of checks and balances to ensure high standards of scholarship and financial integrity at every stage of a grant’s lifecycle. Here’s how it all works.

The birth of a grant application

To receive research funding, scientists submit grant applications to specific programs. A cancer researcher might apply to the Bioengineering Research Grants program at NIH. Someone investigating sustainable fishing in freshwater habitats could seek funding from the Population and Community Ecology program at the NSF.

Applications must be responsive to the funding program’s specific request for proposals, or RFP. The RFP tells researchers what the agency wants to fund. For example, the NSF’s Education Core Research program currently only funds projects focused on STEM learning.

RFPs might have other application requirements, too, like explaining how a project will contribute to the public good, or supporting training for new scientists.

Grant applications have two main parts. First, the researcher presents an extensive literature review to explain why the new project is needed and what it will add to the existing knowledge base. Next, they write up a detailed description of the proposed research plan. This basic two-part structure ensures that funded research will yield important information that is both new and trustworthy.

Reviewers read the grant applications and compare them to the RFP. Applications that don’t address all the topics and research priorities listed there are unlikely to be funded. I once had a proposal rejected without further review because I left out a paragraph addressing one of the items in the agency’s new RFP. This initial review for RFP compliance is called “triage” and, believe me, nobody wants to see their hard work triaged out of the running.

out of focus view of several people seated and standing around a conference table
A panel of anonymous content experts carefully reviews applications to see if they’re worth funding.
PeopleImages/iStock via Getty Images Plus

Merit review: How funding decisions are made

Federal funding decisions are made through rigorous merit review.

For each round of funding, agencies assemble a panel of anonymous content experts who will look for strengths and weaknesses in the proposals – anything from innovation in the question posed to logical flaws in the hypotheses or technical problems with the planned data analyses. With a group of experts looking for every possible weakness, having your grant reviewed is a bit like running a gauntlet.

This careful review might help explain why 70% to 80% of grant applications typically go unfunded at agencies like the NIH and the NSF. But this level of scrutiny is necessary to prevent funding poorly designed or low-impact research.

Several safeguards head off bias or unethical influences during merit review.

First, reviewers must disclose any conflicts of interest with the pool of applicants before they can access the applications. Conflicts of interest can include situations like the reviewer having been the student of an applicant, the applicant and reviewer being divorced, or the proposal coming from the reviewer’s current institution.

When conflicts are identified, the reviewer can remain on the panel, but they are completely excluded from decisions related to that application. They cannot even be in the room when it is discussed.

Second, reviewers usually attend a meeting, supervised by program staff from the funding agency, where everyone debates the proposal’s merits before they score it. Sometimes panel members disagree in their initial critiques and use the meeting to hash out their differences. Other times, a reviewer might raise an important concern that others missed.

Group discussion helps ensure a transparent and thorough review. It also stops any single reviewer from dictating the fate of a proposal because everyone hears the discussion and then scores the proposal individually. Whether a reviewer thinks an application is outstanding or fatally flawed, they must convince the rest of the experts in the room for the group’s overall scores to be greatly affected.

Third, these discussions, along with the applications themselves and any written critiques, are strictly confidential. Reviewers sign written confidentiality agreements under penalty of perjury. This practice stops panelists from scoring political points by telling an applicant they defended their proposal, or divulging trade secrets and proprietary information.

Following the meeting, final decisions are made by program staff using the reviewers’ evaluations. Some agencies adhere closely to the reviewers’ numeric scores – like a grade – when making these decisions. Others ask reviewers to sort applications into “fundable” or “non-fundable” piles; program staff then have some discretion on the final decision. But all decisions are rooted in the peer critiques.

chest of someone seated at desk with calculator and a lot of receipts
Researchers and their institutions keep careful records of where every penny gets spent.
krisanapong detraphiphat/Moment

Spending the funds

Headlines about universities receiving large grants may leave the impression that such funds are simply added to the institution’s general coffers. But research funds are granted to support specific research projects, and agencies have strict rules about spending the money.

For example, if a researcher wants to present their findings at a conference, they can charge the grant for their travel costs, but they may not charge above a certain amount for their lodging or purchase business class airplane tickets. Similarly, if a researcher wants to have more time to devote to a funded project, they can use part of the money to pay their own salary in the summer, but there are precise limits on the amount of funding that can be used for this purpose.

It’s not up to the researcher alone to follow these rules. The organization that employs the researcher, usually a university, enforces the agency rules because it’s the employing organization that controls the grant accounts.

Returning to the conference travel example, a university researcher who wants to attend a conference must request permission and provide a budget for the trip before purchasing tickets. If the travel request is approved by their department chair, dean and the university travel office, they may go ahead with their reservations. However, if they don’t produce receipts when they return, they will not be allowed to charge the grant. The same process applies to buying new computers for the lab, ordering standardized tests for a study or purchasing gift cards for study participants.

Research organizations are highly motivated to enforce spending rules properly, because everyone in the organization is at risk of losing access to federal funds in the future if they let things slide. Funding agencies also require periodic reports and sometimes conduct audits to ensure compliance. These practices help guard against any misuse of funds.

The way agencies issue grants to researchers isn’t perfect. But processes like issuing detailed RFPs, conducting merit reviews and monitoring financial compliance go a long way toward protecting the integrity of the research funding process.The Conversation

Kelly S. Mix, Associate Dean for Research, Innovation, and Partnerships in the College of Education, University of Maryland

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The post Lifecycle of a research grant – behind the scenes of the system that funds science appeared first on theconversation.com



Note: The following A.I. based commentary is not part of the original article, reproduced above, but is offered in the hopes that it will promote greater media literacy and critical thinking, by making any potential bias more visible to the reader –Staff Editor.

Political Bias Rating: Centrist

This article presents a factual, procedural explanation of how research funding works in the United States, focusing on the systems, checks, and safeguards in place for grant application, review, and spending. It avoids ideological language or partisan framing, instead emphasizing transparency, merit-based decision-making, and accountability within federal funding agencies. The tone is neutral and informational, intended to clarify a complex process rather than advocate for any political viewpoint. Overall, the content reflects a balanced, nonpartisan stance centered on explaining government operations in research funding.

The Conversation

How federal officials talk about health is shifting in troubling ways – and that change makes me worried for my autistic child

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theconversation.com – Megan Donelson, Lecturer in Health Rhetorics, University of Dayton – 2025-08-25 07:08:00


The Make America Healthy Again (MAHA) movement, led by Robert F. Kennedy Jr., emphasizes personal responsibility for health, framing chronic illnesses, including autism, as largely preventable through lifestyle changes. MAHA’s rhetoric neglects systemic factors like genetics, environmental exposures, and inequalities in healthcare access, fueling concerns in disability and chronic illness communities about blame shifting from government to individuals. Critics highlight MAHA’s reduction in autism research funding and worry its approach could jeopardize essential support systems. The movement also employs tactics like questioning established science, undermining public trust in medicine. Though its goals of healthier environments are popular, MAHA’s underlying agenda raises ethical and social concerns.

Blaming poor health outcomes on lifestyle choices can obscure public health issues.
Anadolu via Getty Images

Megan Donelson, University of Dayton

The Make America Healthy Again movement has generated a lot of discussion about public health. But the language MAHA proponents use to describe health and disease has also raised concerns among the disability and chronic illness communities.

I’m a researcher studying the rhetoric of health and medicine – and, specifically, the rhetoric of risk. This means I analyze the language used by public officials, institutions, health care providers and other groups in discussing health risks to decode the underlying beliefs and assumptions that can affect both policy and public sentiment about health issues.

As a scholar of rhetoric and the mother of an autistic child, in the language of MAHA I hear a disregard for the humanity of people with disabilities and a shift from supporting them to blaming them for their needs.

Such language goes all the way up to the MAHA movement’s highest-level leader, Health and Human Services Secretary Robert F. Kennedy Jr. It is clearly evident in the report on children’s health published in May 2025 by the MAHA Commission, which was established by President Donald Trump and is led by Kennedy, as well as in the MAHA Commission’s follow-up draft recommendations, leaked on Aug. 15, 2025.

Like many people, I worry that the MAHA Commission’s rhetoric may signal a coming shift in how the federal government views the needs of people with disabilities – and its responsibilities for meeting them.

Personal choice in health

One key concept for understanding the MAHA movement’s rhetoric, introduced by a prominent sociologist named Ulrich Beck, is what sociologists now call individualization of risk. Beck argued that modern societies and governments frame almost all health risks as being about personal choice and responsibility. That approach obscures how policies made by large institutions – such as governments, for example – constrain the choices that people are able to make.

In other words, governments and other institutions tend to focus on the choices that individuals make to intentionally deflect from their own responsibility for the other risk factors. The consequence, in many cases, is that the institution is off the hook for any responsibility for negative outcomes.

Beck, writing in 1986, pointed to nuclear plants in the Soviet Union as an example. People who lived near them reported health issues that they suspected were caused by radiation. But the government denied the existence of any evidence linking their woes to radiation exposure, implying that lifestyle choices were to blame. Some scholars have identified a similar dynamic in the U.S. today, where the government emphasizes personal responsibility while downplaying the effects of public policy on health outcomes.

A shift in responsibility

Such a shift in responsibility is evident in how MAHA proponents, including Kennedy, discuss chronic illness and disabilities – in particular, autism.

In its May 2025 report on children’s health, the MAHA Commission describes the administration’s views on chronic diseases in children. The report notes that the increased prevalence in “obesity, diabetes, neurodevelopmental disorders, cancer, mental health, autoimmune disorders and allergies” are “preventable trends.” It also frames the “major drivers” of these trends as “the food children are eating, the chemicals they are exposed to, the medications they are taking, and various changes to their lifestyle and behavior, particularly those related to physical activity, sleep and the use of technology.”

A father and a boy with autism play with toys at a table.
Extensive research shows that genetics accounts for most of the risk of developing autism, but the MAHA Commission report discussed only lifestyle and environmental factors.
Dusan Stankovic/E+ via Getty Images

Notably, it makes no mention of systemic problems, such as limited access to nutritious food, poor air quality and lack of access to health care, despite strong evidence for the enormous contributions these factors make to children’s health. And regarding neurodevelopmental disorders such as autism, it makes no mention of genetics, even though decades of research has found that genetics accounts for most of the risk of developing autism.

There’s nothing inherently wrong with studying the environmental factors that might contribute to autism or other neurodevelopmental disorders. In fact, many researchers believe that autism is caused by complex interactions between genes and environmental factors. But here’s where Beck’s concept of individualization becomes revealing: While the government is clearly not responsible for the genetic causes of chronic diseases, this narrow focus on lifestyle and environmental factors implies that autism can be prevented if these factors are altered or eliminated.

While this may sound like great news, there are a couple of problems. First, it’s simply not true. Second, the Trump administration and Kennedy have canceled tens of millions of dollars in research funding for autism – including on environmental causes – replacing it with an initiative with an unclear review process. This is an unusual move if the goal is to identify and mitigate environmental risk factors And finally, the government could use this claim to justify removing federally funded support systems that are essential for the well-being of autistic people and their families – and instead focus all its efforts on eliminating processed foods, toxins and vaccines.

People with autism and their families are already carrying a tremendous financial burden, even with the current sources of available support. Cuts to Medicaid and other funding could transfer the responsibility for therapies and other needs to individual families, leaving many of them to struggle with paying their medical bills. But it could also threaten the existence of an entire network of health care providers that people with disabilities rely on.

Even more worrisome is the implication that autism is a kind of damage caused by the environment rather than one of many normal variations in human neurological diversity – framing people with autism as a problem that society must solve.

How language encodes value judgments

Such logic sets off alarm bells for anyone familiar with the history of eugenics, a movement that began with the idea of improving America by making its people healthier and quickly evolved to make judgments about who is and is not fit to participate in society.

Kennedy’s explanation for the rise in autism diagnoses contradicts decades of research by independent researchers as well as assessments by the CDC.

Kennedy has espoused this view of autism throughout his career, even recently claiming that people with autism “will never pay taxes. They’ll never hold a job. They’ll never play baseball. They’ll never write a poem.”

Even if organic foods and a toxin-free household were the answer to reducing the prevalence of autism, the leaked MAHA Commission strategy report steers clear of recommending government regulation in industries such as food and agriculture, which would be needed to make these options affordable and widely available.

Instead, MAHA’s supposed interventions would remain lifestyle choices – and expensive ones, at that – left for individual families to make for themselves.

Just asking questions

Kennedy and other MAHA proponents also employ another powerful rhetorical tactic: raising questions about topics that have already reached a scientific consensus. This tactic frames such questions as pursuits of truth, but their purpose is actually to create doubt. This tactic, too, is evident in the MAHA Commission’s reports.

This practice of “just asking questions” while ignoring already established answers is widely referred to as “sealioning.” The tactic, named for a notorious sea lion in an online comic called Wondermark, is considered a form of harassment. Like much of the rhetoric of the anti-vaccine movement, it
serves to undermine public trust in science and medicine. This is partly due to a widespread misunderstanding of scientific research – for example, understanding that scientific disagreement does not necessarily indicate that science as a process is flawed.

MAHA rhetoric thus continues a troubling trend in the anti-vaccine movement of calling all of science and Western medicine into question in order to further a specific agenda, regardless of the risks to public health.

The MAHA Commission’s goals are almost universally appealing – healthier food, healthier kids and a healthier environment for all Americans. But analyzing what is implied, minimized or left out entirely can illuminate a much more complex political and social agenda.The Conversation

Megan Donelson, Lecturer in Health Rhetorics, University of Dayton

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Extensive research shows that genetics accounts for most of the risk of developing autism, but the MAHA Commission report discussed only lifestyle and environmental factors.
Dusan Stankovic/E+ via Getty Images

Notably, it makes no mention of systemic problems, such as limited access to nutritious food, poor air quality and lack of access to health care, despite strong evidence for the enormous contributions these factors make to children’s health. And regarding neurodevelopmental disorders such as autism, it makes no mention of genetics, even though decades of research has found that genetics accounts for most of the risk of developing autism.

There’s nothing inherently wrong with studying the environmental factors that might contribute to autism or other neurodevelopmental disorders. In fact, many researchers believe that autism is caused by complex interactions between genes and environmental factors. But here’s where Beck’s concept of individualization becomes revealing: While the government is clearly not responsible for the genetic causes of chronic diseases, this narrow focus on lifestyle and environmental factors implies that autism can be prevented if these factors are altered or eliminated.

While this may sound like great news, there are a couple of problems. First, it’s simply not true. Second, the Trump administration and Kennedy have canceled tens of millions of dollars in research funding for autism – including on environmental causes – replacing it with an initiative with an unclear review process. This is an unusual move if the goal is to identify and mitigate environmental risk factors And finally, the government could use this claim to justify removing federally funded support systems that are essential for the well-being of autistic people and their families – and instead focus all its efforts on eliminating processed foods, toxins and vaccines.

People with autism and their families are already carrying a tremendous financial burden, even with the current sources of available support. Cuts to Medicaid and other funding could transfer the responsibility for therapies and other needs to individual families, leaving many of them to struggle with paying their medical bills. But it could also threaten the existence of an entire network of health care providers that people with disabilities rely on.

Even more worrisome is the implication that autism is a kind of damage caused by the environment rather than one of many normal variations in human neurological diversity – framing people with autism as a problem that society must solve.

How language encodes value judgments

Such logic sets off alarm bells for anyone familiar with the history of eugenics, a movement that began with the idea of improving America by making its people healthier and quickly evolved to make judgments about who is and is not fit to participate in society.

Kennedy’s explanation for the rise in autism diagnoses contradicts decades of research by independent researchers as well as assessments by the CDC.

Kennedy has espoused this view of autism throughout his career, even recently claiming that people with autism “will never pay taxes. They’ll never hold a job. They’ll never play baseball. They’ll never write a poem.”

Even if organic foods and a toxin-free household were the answer to reducing the prevalence of autism, the leaked MAHA Commission strategy report steers clear of recommending government regulation in industries such as food and agriculture, which would be needed to make these options affordable and widely available.

Instead, MAHA’s supposed interventions would remain lifestyle choices – and expensive ones, at that – left for individual families to make for themselves.

Just asking questions

Kennedy and other MAHA proponents also employ another powerful rhetorical tactic: raising questions about topics that have already reached a scientific consensus. This tactic frames such questions as pursuits of truth, but their purpose is actually to create doubt. This tactic, too, is evident in the MAHA Commission’s reports.

This practice of “just asking questions” while ignoring already established answers is widely referred to as “sealioning.” The tactic, named for a notorious sea lion in an online comic called Wondermark, is considered a form of harassment. Like much of the rhetoric of the anti-vaccine movement, it
serves to undermine public trust in science and medicine. This is partly due to a widespread misunderstanding of scientific research – for example, understanding that scientific disagreement does not necessarily indicate that science as a process is flawed.

MAHA rhetoric thus continues a troubling trend in the anti-vaccine movement of calling all of science and Western medicine into question in order to further a specific agenda, regardless of the risks to public health.

The MAHA Commission’s goals are almost universally appealing – healthier food, healthier kids and a healthier environment for all Americans. But analyzing what is implied, minimized or left out entirely can illuminate a much more complex political and social agenda.

Read More

The post How federal officials talk about health is shifting in troubling ways – and that change makes me worried for my autistic child appeared first on theconversation.com



Note: The following A.I. based commentary is not part of the original article, reproduced above, but is offered in the hopes that it will promote greater media literacy and critical thinking, by making any potential bias more visible to the reader –Staff Editor.

Political Bias Rating: Center-Left

The content critically examines the Make America Healthy Again (MAHA) movement and its leadership, particularly focusing on Health and Human Services Secretary Robert F. Kennedy Jr. and the Trump administration’s policies. It highlights concerns about shifting responsibility for public health from government institutions to individuals, critiques the downplaying of systemic issues, and warns against rhetoric that could harm disabled communities. The analysis aligns with a center-left perspective by emphasizing social responsibility, government accountability, and skepticism toward right-leaning health policy approaches that prioritize personal responsibility over structural support.

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The Conversation

The first stars may not have been as uniformly massive as astronomers thought

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theconversation.com – Luke Keller, Professor of Physics and Astronomy, Ithaca College – 2025-08-22 07:27:00


For decades, astronomers believed the first stars were massive, short-lived, and composed only of hydrogen and helium, ending in supernovae without forming planets. However, two 2025 studies challenge this view. One simulation shows turbulence in early gas clouds caused fragmentation, allowing lower-mass stars to form. Another experiment reveals helium hydride (HeH⁺), previously thought inert, catalyzed early molecular hydrogen (H₂) formation, enhancing cooling and enabling smaller clouds to collapse. These findings suggest the earliest stars included low-mass stars that may still exist today, potentially hosting the first planets. Observational confirmation remains challenging due to their faintness.

Stars form in the universe from massive clouds of gas.
European Southern Observatory, CC BY-SA

Luke Keller, Ithaca College

For decades, astronomers have wondered what the very first stars in the universe were like. These stars formed new chemical elements, which enriched the universe and allowed the next generations of stars to form the first planets.

The first stars were initially composed of pure hydrogen and helium, and they were massive – hundreds to thousands of times the mass of the Sun and millions of times more luminous. Their short lives ended in enormous explosions called supernovae, so they had neither the time nor raw materials to form planets, and they should no longer exist for astronomers to observe.

At least that’s what we thought.

Two studies published in the first half of 2025 suggest that collapsing gas clouds in the early universe may have formed lower-mass stars as well. One study uses a new astrophysical computer simulation that models turbulence within the cloud, causing fragmentation into smaller, star-forming clumps. The other study – an independent laboratory experiment – demonstrates how molecular hydrogen, a molecule essential for star formation, may have formed earlier and in larger abundances. The process involves a catalyst that may surprise chemistry teachers.

As an astronomer who studies star and planet formation and their dependence on chemical processes, I am excited at the possibility that chemistry in the first 50 million to 100 million years after the Big Bang may have been more active than we expected.

These findings suggest that the second generation of stars – the oldest stars we can currently observe and possibly the hosts of the first planets – may have formed earlier than astronomers thought.

Primordial star formation

Video illustration of the star and planet formation process. Credit: Space Telescope Science Institute.

Stars form when massive clouds of hydrogen many light years across collapse under their own gravity. The collapse continues until a luminous sphere surrounds a dense core that is hot enough to sustain nuclear fusion.

Nuclear fusion happens when two or more atoms gain enough energy to fuse together. This process creates a new element and releases an incredible amount of energy, which heats the stellar core. In the first stars, hydrogen atoms fused together to create helium.

The new star shines because its surface is hot, but the energy fueling that luminosity percolates up from its core. The luminosity of a star is its total energy output in the form of light. The star’s brightness is the small fraction of that luminosity that we directly observe.

This process where stars form heavier elements by nuclear fusion is called stellar nucleosynthesis. It continues in stars after they form as their physical properties slowly change. The more massive stars can produce heavier elements such as carbon, oxygen and nitrogen, all the way up to iron, in a sequence of fusion reactions that end in a supernova explosion.

Supernovae can create even heavier elements, completing the periodic table of elements. Lower-mass stars like the Sun, with their cooler cores, can sustain fusion only up to carbon. As they exhaust the hydrogen and helium in their cores, nuclear fusion stops and the stars slowly evaporate.

Two images showing spherical illustrations. The left shows a star exploding, shooting out colorful tendrils of light and color. The right shows a cloud of gas fading away.
The remnant of a high-mass star supernova explosion imaged by the Chandra X-ray Observatory, left, and the remnant of a low-mass star evaporating in a blue bubble, right.
CC BY

High-mass stars have high pressure and temperature in their cores, so they burn bright and use up their gaseous fuel quickly. They last only a few million years, whereas low-mass stars – those less than two times the Sun’s mass – evolve much more slowly, with lifetimes of billions or even trillions of years.

If the earliest stars were all high-mass stars, then they would have exploded long ago. But if low-mass stars also formed in the early universe, they may still exist for us to observe.

Chemistry that cools clouds

The first star-forming gas clouds, called protostellar clouds, were warm – roughly room temperature. Warm gas has internal pressure that pushes outward against the inward force of gravity trying to collapse the cloud. A hot air balloon stays inflated by the same principle. If the flame heating the air at the base of the balloon stops, the air inside cools and the balloon begins to collapse.

Two bright clouds of gas condensing around a small central region
Stars form when clouds of dust collapse inward and condense around a small, bright, dense core.
NASA, ESA, CSA, and STScI, J. DePasquale (STScI), CC BY-ND

Only the most massive protostellar clouds with the most gravity could overcome the thermal pressure and eventually collapse. In this scenario, the first stars were all massive.

The only way to form the lower-mass stars we see today is for the protostellar clouds to cool. Gas in space cools by radiation, which transforms thermal energy into light that carries the energy out of the cloud. Hydrogen and helium atoms are not efficient radiators below several thousand degrees, but molecular hydrogen, H₂, is great at cooling gas at low temperatures.

When energized, H₂ emits infrared light, which cools the gas and lowers the internal pressure. That process would make gravitational collapse more likely in lower-mass clouds.

For decades, astronomers have reasoned that a low abundance of H₂ early on resulted in hotter clouds whose internal pressure would be too hot to easily collapse into stars. They concluded that only clouds with enormous masses, and therefore higher gravity, would collapse – leaving more massive stars.

Helium hydride

In a July 2025 journal article, physicist Florian Grussie and collaborators at the Max Planck Institute for Nuclear Physics demonstrated that the first molecule to form in the universe, helium hydride, HeH⁺, could have been more abundant in the early universe than previously thought. They used a computer model and conducted a laboratory experiment to verify this result.

Helium hydride? In high school science you probably learned that helium is a noble gas, meaning it does not react with other atoms to form molecules or chemical compounds. As it turns out, it does – but only under the extremely sparse and dark conditions of the early universe, before the first stars formed.

HeH⁺ reacts with hydrogen deuteride – HD, which is one normal hydrogen atom bonded to a heavier deuterium atom – to form H₂. In the process, HeH⁺ also acts as a coolant and releases heat in the form of light. So, the high abundance of both molecular coolants earlier on may have allowed smaller clouds to cool faster and collapse to form lower-mass stars.

Gas flow also affects stellar initial masses

In another study, published in July 2025, astrophysicist Ke-Jung Chen led a research group at the Academia Sinica Institute of Astronomy and Astrophysics using a detailed computer simulation that modeled how gas in the early universe may have flowed.

The team’s model demonstrated that turbulence, or irregular motion, in giant collapsing gas clouds can form lower-mass cloud fragments from which lower-mass stars condense.

The study concluded that turbulence may have allowed these early gas clouds to form stars either the same size or up to 40 times more massive than the Sun’s mass.

A clump of small bright dots representing stars, shown near a bright spot in the center of the image.
The galaxy NGC 1140 is small and contains large amounts of primordial gas with far fewer elements heavier than hydrogen and helium than are present in our Sun. This composition makes it similar to the intensely star-forming galaxies found in the early universe. These early universe galaxies were the building blocks for large galaxies such as the Milky Way.
ESA/Hubble & NASA, CC BY-ND

The two new studies both predict that the first population of stars could have included low-mass stars. Now, it is up to us observational astronomers to find them.

This is no easy task. Low-mass stars have low luminosities, so they are extremely faint. Several observational studies have recently reported possible detections, but none are yet confirmed with high confidence. If they are out there, though, we will find them eventually.The Conversation

Luke Keller, Professor of Physics and Astronomy, Ithaca College

This article is republished from The Conversation under a Creative Commons license. Read the original article.

The remnant of a high-mass star supernova explosion imaged by the Chandra X-ray Observatory, left, and the remnant of a low-mass star evaporating in a blue bubble, right.
CC BY

High-mass stars have high pressure and temperature in their cores, so they burn bright and use up their gaseous fuel quickly. They last only a few million years, whereas low-mass stars – those less than two times the Sun’s mass – evolve much more slowly, with lifetimes of billions or even trillions of years.

If the earliest stars were all high-mass stars, then they would have exploded long ago. But if low-mass stars also formed in the early universe, they may still exist for us to observe.

Chemistry that cools clouds

The first star-forming gas clouds, called protostellar clouds, were warm – roughly room temperature. Warm gas has internal pressure that pushes outward against the inward force of gravity trying to collapse the cloud. A hot air balloon stays inflated by the same principle. If the flame heating the air at the base of the balloon stops, the air inside cools and the balloon begins to collapse.

Two bright clouds of gas condensing around a small central region

Stars form when clouds of dust collapse inward and condense around a small, bright, dense core.
NASA, ESA, CSA, and STScI, J. DePasquale (STScI), CC BY-ND

Only the most massive protostellar clouds with the most gravity could overcome the thermal pressure and eventually collapse. In this scenario, the first stars were all massive.

The only way to form the lower-mass stars we see today is for the protostellar clouds to cool. Gas in space cools by radiation, which transforms thermal energy into light that carries the energy out of the cloud. Hydrogen and helium atoms are not efficient radiators below several thousand degrees, but molecular hydrogen, H₂, is great at cooling gas at low temperatures.

When energized, H₂ emits infrared light, which cools the gas and lowers the internal pressure. That process would make gravitational collapse more likely in lower-mass clouds.

For decades, astronomers have reasoned that a low abundance of H₂ early on resulted in hotter clouds whose internal pressure would be too hot to easily collapse into stars. They concluded that only clouds with enormous masses, and therefore higher gravity, would collapse – leaving more massive stars.

Helium hydride

In a July 2025 journal article, physicist Florian Grussie and collaborators at the Max Planck Institute for Nuclear Physics demonstrated that the first molecule to form in the universe, helium hydride, HeH⁺, could have been more abundant in the early universe than previously thought. They used a computer model and conducted a laboratory experiment to verify this result.

Helium hydride? In high school science you probably learned that helium is a noble gas, meaning it does not react with other atoms to form molecules or chemical compounds. As it turns out, it does – but only under the extremely sparse and dark conditions of the early universe, before the first stars formed.

HeH⁺ reacts with hydrogen deuteride – HD, which is one normal hydrogen atom bonded to a heavier deuterium atom – to form H₂. In the process, HeH⁺ also acts as a coolant and releases heat in the form of light. So, the high abundance of both molecular coolants earlier on may have allowed smaller clouds to cool faster and collapse to form lower-mass stars.

Gas flow also affects stellar initial masses

In another study, published in July 2025, astrophysicist Ke-Jung Chen led a research group at the Academia Sinica Institute of Astronomy and Astrophysics using a detailed computer simulation that modeled how gas in the early universe may have flowed.

The team’s model demonstrated that turbulence, or irregular motion, in giant collapsing gas clouds can form lower-mass cloud fragments from which lower-mass stars condense.

The study concluded that turbulence may have allowed these early gas clouds to form stars either the same size or up to 40 times more massive than the Sun’s mass.

A clump of small bright dots representing stars, shown near a bright spot in the center of the image.

The galaxy NGC 1140 is small and contains large amounts of primordial gas with far fewer elements heavier than hydrogen and helium than are present in our Sun. This composition makes it similar to the intensely star-forming galaxies found in the early universe. These early universe galaxies were the building blocks for large galaxies such as the Milky Way.
ESA/Hubble & NASA, CC BY-ND

The two new studies both predict that the first population of stars could have included low-mass stars. Now, it is up to us observational astronomers to find them.

This is no easy task. Low-mass stars have low luminosities, so they are extremely faint. Several observational studies have recently reported possible detections, but none are yet confirmed with high confidence. If they are out there, though, we will find them eventually.

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The post The first stars may not have been as uniformly massive as astronomers thought appeared first on theconversation.com



Note: The following A.I. based commentary is not part of the original article, reproduced above, but is offered in the hopes that it will promote greater media literacy and critical thinking, by making any potential bias more visible to the reader –Staff Editor.

Political Bias Rating: Centrist

This content is a scientific article focusing on astronomy and astrophysics, discussing recent research on the formation of the first stars in the universe. It presents factual information, references scientific studies, and avoids political or ideological language. The neutrality and objectivity in reporting scientific findings indicate no evident political bias, making it centrist in nature.

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The Conversation

Pediatricians’ association recommends COVID-19 vaccines for toddlers and some older children, breaking with CDC guidance

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theconversation.com – David Higgins, Assistant Professor of Pediatrics, University of Colorado Anschutz Medical Campus – 2025-08-20 12:57:00


In August 2025, the American Academy of Pediatrics (AAP) issued new COVID-19 vaccine recommendations for children, diverging from the CDC’s guidance for the first time in 30 years. The AAP advises all children 6–23 months receive a full vaccine series and recommends a single dose for higher-risk children aged 2–18, while keeping vaccines available for others. This contrasts with the CDC’s “shared clinical decision-making” approach, which leaves vaccination decisions to families and providers. The divergence follows federal changes affecting vaccine advisory panels, raising concerns about CDC guidance credibility. Vaccine access, insurance coverage, and supply remain uncertain, potentially complicating implementation.

The AAP’s guidance on COVID-19 vaccines differs substantially from that of the CDC.
Images By Tang Ming Tung/DigitalVision via Getty Images

David Higgins, University of Colorado Anschutz Medical Campus

For 30 years, vaccine recommendations from the Centers for Disease Control and Prevention have aligned closely with those from the American Academy of Pediatrics, or AAP. But on Aug. 19, 2025, the AAP published new vaccine recommendations that diverge from those of the CDC.

The pediatrician association’s move comes on the heels of unprecedented changes made earlier this year by Robert F. Kennedy Jr., as head of the Department of Health and Human Services, in how the government approves and issues guidance on vaccines.

The biggest difference is in the AAP’s guidance around COVID-19 vaccines for children. This new guidance comes as COVID-19 cases are once again rising across the U.S. and many parents and providers are confused by unclear guidance from federal health authorities about whether children should be vaccinated.

In a Q&A with The Conversation U.S., David Higgins, a pediatrician, preventive medicine physician and vaccine delivery researcher from the University of Colorado Anschutz Medical Campus, explains the new guidance and what it means for parents. Higgins is also a member of the American Academy of Pediatrics.

Pediatrician and preventive medicine specialist David Higgins explains the guidance in this video.

What are the AAP’s new vaccine recommendations?

The AAP recommends that all children 6 to 23 months old receive a complete COVID-19 vaccine series, consistent with recommendations for this age group in previous years.

For children and adolescents ages 2 to 18, the AAP now advises a single dose if they are at higher risk, a change from previous years, when vaccination was recommended for all in this age group. Children at higher risk include those who have certain chronic medical conditions, who live in long-term care or group settings, who have never been vaccinated, or who live with family members at high risk.

The AAP also recommends that COVID-19 vaccines remain available for any child or adolescent whose parent wants them to be protected, regardless of risk status. In all cases, the most updated version of the vaccine should be used.

How do these recommendations differ from CDC guidance?

The difference is substantial. The CDC currently advises what it calls “shared clinical decision-making” for children ages 6 months to 17 years who are not moderately or severely immunocompromised. This means the decision is left up to individual discussions between families and their health care providers, but the vaccine is not treated as a routine recommendation. These current guidelines were made after Kennedy bypassed the agency’s normal independent review process.

That framework can be confusing for families and difficult for providers to implement. By contrast, the AAP recommendations identify the ages and conditions where the risk is highest while also supporting vaccine availability for any families who want it.

Toddlers engaged in an activity at a wooden table in a classroom.
It’s not clear whether families will be able to access routine COVID-19 vaccines for children this fall.
Pancake Pictures/Connect Images via Getty Images

Why are they diverging?

The AAP has been publishing vaccine guidance since the 1930s, long before the CDC or the Advisory Committee on Immunization Practices, an independent panel of experts that advises the CDC, existed.

Since 1995, the two groups have generally issued essentially identical vaccine guidance. But this year, the federal government dismissed the advisory committee’s panel of independent scientists and immunization experts, raising questions about the credibility of CDC guidance. At the same time, misinformation about vaccines continues to spread.

In response, the AAP decided to publish independent recommendations based on its own review of the latest evidence. That review showed that although the risks for healthy older children have declined compared with the early years of the pandemic, young children and those with specific conditions remain especially vulnerable. Additionally, a review of evidence by an independent expert group called the Vaccine Integrity Project, also released on Aug. 19, 2025, confirmed that there are no new safety concerns and no decline in the effectiveness of COVID-19 vaccines.

COVID-19 continues to cause hospitalizations and deaths in children and remains a leading cause of serious respiratory illness.

Will parents be able to follow these recommendations?

This is still unclear. The AAP recommendations do not automatically guarantee insurance coverage.

By law, insurance plans and the federal Vaccines for Children program, which provides vaccines for eligible children who might not otherwise be vaccinated due to cost or lack of insurance, are tied to Advisory Committee on Immunization Practices recommendations. Unless insurers and policymakers act to align with the AAP recommendations, there is a risk that parents would be forced to pay the costs out of pocket.

Vaccine supply may also be an issue. Currently, only two COVID-19 vaccines are available for children under 12. Moderna’s vaccine is approved only for children with at least one high-risk condition, while Pfizer’s authorization for younger children may not be renewed. If that happens, any remaining Pfizer doses for this age group may be unusable, leaving a shortfall in available vaccines for children.

Finally, implementation may differ depending on the type of provider. Some vaccine providers, such as pharmacists, operate under policies tied strictly to CDC recommendations, which may make it harder to follow AAP’s schedule unless rules are updated.

What happens next?

Parents and providers are likely to face continued confusion, just as COVID-19 cases rise as children return to school. Much will depend on whether the Advisory Committee on Immunization Practices updates its own recommendations at its upcoming meeting, expected in September, and whether pediatric COVID-19 vaccines remain available.

Until then, parents can speak with their pediatricians to understand the best protection for their children.The Conversation

David Higgins, Assistant Professor of Pediatrics, University of Colorado Anschutz Medical Campus

This article is republished from The Conversation under a Creative Commons license. Read the original article.

It’s not clear whether families will be able to access routine COVID-19 vaccines for children this fall.
Pancake Pictures/Connect Images via Getty Images

Why are they diverging?

The AAP has been publishing vaccine guidance since the 1930s, long before the CDC or the Advisory Committee on Immunization Practices, an independent panel of experts that advises the CDC, existed.

Since 1995, the two groups have generally issued essentially identical vaccine guidance. But this year, the federal government dismissed the advisory committee’s panel of independent scientists and immunization experts, raising questions about the credibility of CDC guidance. At the same time, misinformation about vaccines continues to spread.

In response, the AAP decided to publish independent recommendations based on its own review of the latest evidence. That review showed that although the risks for healthy older children have declined compared with the early years of the pandemic, young children and those with specific conditions remain especially vulnerable. Additionally, a review of evidence by an independent expert group called the Vaccine Integrity Project, also released on Aug. 19, 2025, confirmed that there are no new safety concerns and no decline in the effectiveness of COVID-19 vaccines.

COVID-19 continues to cause hospitalizations and deaths in children and remains a leading cause of serious respiratory illness.

Will parents be able to follow these recommendations?

This is still unclear. The AAP recommendations do not automatically guarantee insurance coverage.

By law, insurance plans and the federal Vaccines for Children program, which provides vaccines for eligible children who might not otherwise be vaccinated due to cost or lack of insurance, are tied to Advisory Committee on Immunization Practices recommendations. Unless insurers and policymakers act to align with the AAP recommendations, there is a risk that parents would be forced to pay the costs out of pocket.

Vaccine supply may also be an issue. Currently, only two COVID-19 vaccines are available for children under 12. Moderna’s vaccine is approved only for children with at least one high-risk condition, while Pfizer’s authorization for younger children may not be renewed. If that happens, any remaining Pfizer doses for this age group may be unusable, leaving a shortfall in available vaccines for children.

Finally, implementation may differ depending on the type of provider. Some vaccine providers, such as pharmacists, operate under policies tied strictly to CDC recommendations, which may make it harder to follow AAP’s schedule unless rules are updated.

What happens next?

Parents and providers are likely to face continued confusion, just as COVID-19 cases rise as children return to school. Much will depend on whether the Advisory Committee on Immunization Practices updates its own recommendations at its upcoming meeting, expected in September, and whether pediatric COVID-19 vaccines remain available.

Until then, parents can speak with their pediatricians to understand the best protection for their children.

Read More

The post Pediatricians’ association recommends COVID-19 vaccines for toddlers and some older children, breaking with CDC guidance appeared first on theconversation.com



Note: The following A.I. based commentary is not part of the original article, reproduced above, but is offered in the hopes that it will promote greater media literacy and critical thinking, by making any potential bias more visible to the reader –Staff Editor.

Political Bias Rating: Center-Left

This content presents information about COVID-19 vaccine recommendations with a focus on public health and scientific expertise. It highlights concerns about governmental interference in health advisory processes and underscores the importance of independent scientific review, which aligns with a perspective that trusts established medical institutions and prioritizes evidence-based policy. The piece critiques changes made under a politically controversial figure while emphasizing the pediatric community’s stance without displaying partisan rhetoric, situating it slightly left of center due to the emphasis on expert-led health guidance and skepticism toward political disruption in health agencies.

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