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Could a single drug treat the two leading causes of death in the US: cancer and cardiovascular disease?

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Could a single drug treat the two leading causes of death in the US: cancer and cardiovascular disease?

Identifying the commonalities between cardiovascular disease and cancer could to improved treatments for both.
Sveta Zi/iStock via Getty Images Plus

Bryan Smith, Michigan State University

What would you guess are the two biggest killers in the world? Based on media coverage, maybe you guessed gun violence, accidents or . But the top two killers are actually cardiovascular disease and cancer. These two diseases combined account for nearly 50% of deaths in the U.S.

Cardiovascular disease and cancer seem to be quite different on the surface. But newly discovered parallels between the origins and development of these two diseases mean that some treatments may be effective against both.

I am a biomedical engineer who has spent two decades studying and developing ways to improve how travel through the body. It turns out that tiny, engineered nanoparticles that can target specific immune cells may be a way to treat both cancer and cardiovascular disease.

Cardiovascular disease and cancer

Atherosclerosis is the most deadly form of cardiovascular disease. It results from inflammation and the buildup of fat, cholesterol and other lipids in the blood vessel wall, forming a plaque. Most heart attacks are caused by plaque rupture. The body's attempt to heal the wound can form a blood clot that blocks blood vessels and result in a heart attack.

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On the other hand, cancer usually arises from genetic mutations that make cells divide uncontrollably. Unrestrainable, rapid cell growth that is untreated can be destructive because it is difficult to stop without harming healthy organs. Cancer can start from and occur in any organ of the body.

Although cardiovascular disease and cancer appear to have different origins and causes, they share many risk factors. For example, obesity, smoking, chronic stress and certain lifestyle choices like poor diet are linked to both diseases. Why might these two diseases share similar risk factors?

Many of the similarities between cardiovascular disease and cancer can be traced to inflammation. Chronic inflammation is a primary cause of atherosclerosis by damaging the cells lining the blood vessels and progressively worsening plaques. Likewise, chronic inflammation can initiate cancer by increasing mutations and support cancer cell survival and spread by increasing the growth of the blood vessels that feed them nutrients and suppressing the body's immune response.

Cardiovascular disease and cancer share many risk factors.

Treating two conditions at once

Research hints that therapies designed for cancer can also treat atherosclerosis.

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One example is drugs that target immune cells called macrophages in tumors and cause them to eat cancer cells. It turns out a similar drug can cause macrophages to clear dead and dying cells in atherosclerosis, which shrinks plaques.

Another example are antiglycolytic therapies that prevent the of glucose. Glucose, or sugar, is the body's main source of energy. These drugs can make diseased tumor blood vessels and atherosclerotic blood vessels look more “normal,” essentially reversing the disease in those vessels. They can also reduce inflammation in atherosclerosis.

Although currently marketed treatments like statins and fibrates can lower lipid levels and blood clotting in atherosclerosis, these drugs have not sufficiently addressed the risk of death from cardiovascular disease. To improve outcomes, clinicians are increasingly using multiple drugs directed against different targets. One intriguing class of treatments is sodium glucose cotransporter-2 inhibitors, which are traditionally used to treat diabetes. Researchers have shown that these drugs both significant protection from cardiovascular disease and treat cancer.

Clinical trials on statins and sodium glucose cotransporter-2 inhibitors indicate a close overlap between inflammation, metabolism and cardiovascular disease that suggests new treatment opportunities. One example is immunotherapies that “inhibit the inhibition” of immunity – that is, they take off the brakes that tumors place on the immune system. This approach to treat cancer also reduced atherosclerotic plaques in animal studies and reduced vascular inflammation in a small study in people.

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A nanomedical Trojan horse

A recent discovery showed that nanotubes – a very small particle made of carbon that is over 10,000 times thinner than a human hair – can go into specific immune cells, travel through the bloodstream and enter tumors as a Trojan horse. These nanotubes can carry anything that researchers put on them, drugs and imaging contrast agents.

The immune cells carrying the nanotubes naturally home in on tumors through the inflammatory response. Since cancer and atherosclerosis are both inflammatory diseases, my research team and I have been studying whether nanotube-loaded immune cells may also serve as delivery vehicles to plaques.

Nanoparticles can be used to “eat” the plaques that cause heart disease.

Nanotubes can be loaded with a therapy that stimulates immune cells to “eat” plaque debris and thus reduce plaque size. Moreover, restricting drug delivery specifically to those immune cells reduces the risk of off-target side effects. These nanotubes can also be used to improve diagnosis of cardiovascular disease by highlighting plaques.

Another way nanoparticles can enter tumors is by squeezing through openings in new blood vessels grown in inflammatory conditions. This is known as the enhanced permeation and retention effect, where larger molecules and nanoparticles accumulate in tissues with leaky blood vessels and remain there for some time because of their size. First discovered in cancer, researchers are applying this effect to improve drug delivery for cardiovascular disease, which can also involve leaky blood vessels.

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Improving drug development

The molecular pathways cancer and cardiovascular disease share have important regulatory implications. The costs involved in getting drugs into the clinic are enormous. The possibility of applying the same drug to two different patient populations offers big financial and risk-reduction incentives. It also offers the potential for simultaneous treatment for with both diseases.

Nanoparticle-based cancer drugs first entered the clinic in 1995, and researchers have developed many others since. But there is currently only one cardiovascular nanodrug approved by the Food and Drug Administration. This suggests for new nanotherapy approaches to improve cardiovascular drug efficacy and reduce side effects.

Because of the parallels between cancer and cardiovascular disease, cancer nanodrugs may be strong drug candidates to treat cardiovascular disease and vice versa. As basic science discovers other molecular parallels between these diseases, patients will be the beneficiaries of better therapies that can treat both.The Conversation

Bryan Smith, Associate Professor of Biomedical Engineering, Michigan State University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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How to tell if a conspiracy theory is probably false

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theconversation.com – H. Colleen Sinclair, Associate Research Professor of Social Psychology, University – 2024-05-07 07:33:01

Conspiracy theories can muddle people's thinking.

Natalie_/iStock / Getty Images Plus

H. Colleen Sinclair, Louisiana State University

Conspiracy theories are everywhere, and they can involve just about anything.

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People believe false conspiracy theories for a wide range of reasons the fact that there are real conspiracies, like efforts by the Sackler to profit by concealing the addictiveness of oxycontin at the cost of countless American lives.

The extreme consequences of unfounded conspiratorial beliefs could be seen on the staircases of the U.S. Capitol on Jan. 6, 2021, and in the self-immolation of a protestor outside the courthouse holding the latest Trump trial.

But if hidden forces really are at work in the world, how is someone to know what's really going on?

That's where my research in; I'm a social psychologist who studies misleading narratives. Here are some ways to vet a claim you've seen or heard.

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An overview of a maze of passages between shrubs.

Sometimes there's nothing but the maze itself.

oversnap/E+ via Getty Images

Step 1: Seek out the evidence

Real conspiracies have been confirmed because there was evidence. For instance, in the allegations dating back to the 1990s that tobacco companies knew cigarettes were dangerous and kept that information secret to make money, scientific studies showed problematic links between tobacco and cancer. Court cases unearthed corporate documents with internal memos showing what executives knew and when. Investigative journalists revealed efforts to hide that information. explained the effects on their patients. Internal whistleblowers sounded the alarm.

But unfounded conspiracy theories reveal their lack of evidence and substitute instead several elements that should be red flags for skeptics:

  • Dismissing traditional sources of evidence, they are in on the plot.

  • Claiming that missing information is because someone is hiding it, even though it's common that not all facts are known completely for some time after an event.

  • Attacking apparent inconsistencies as evidence of lies.

  • Overinterpreting ambiguity as evidence: A flying object may be unidentified – but that's different from identifying it as an alien spaceship.

  • Using anecdotes – especially vaguely attributed ones – in place of evidence, such as “people are saying” such-and-such or “my cousin's friend experienced” something.

  • Attributing knowledge to secret messages that only a select few can grasp – rather than evidence that's plain and clear to all.

Step 2: Test the allegation

Often, a conspiracy theorist presents only evidence that confirms their idea. Rarely do they put their idea to the tests of logic, reasoning and critical thinking.

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While they may say they do research, they typically do not apply the scientific method. Specifically, they don't actually try to prove themselves wrong.

So a skeptic can follow the method scientists use when they do research: Think about what evidence would contradict the explanation – and then go looking for that evidence.

Sometimes that effort will yield confirmation that the explanation is correct. And sometimes not. Like a scientist, ask yourself: What would it take for you to believe your perception was wrong?

A hand holds a magnifying glass over one silhouetted figure, which is connected in a diagram to other figures.

Look closely at allegations of massive conspiracies.

Boris Zhitkov/Moment via Getty Images

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Step 3: Watch out for tangled webs

When theories claim large groups of people are perpetrating wide-ranging activities over a long period of time, that's another red flag.

Confirmed conspiracies typically involve small, isolated groups, like the top echelon of a company or a single terrorist cell. Even the alliance among tobacco companies to hide their products' danger was confined to those at the top, who made decisions and enlisted paid scientists and ad agencies to spread their messages.

False conspiracies tend to implicate wide swaths of people, such as world , mainstream outlets, the global scientific community, the Hollywood entertainment industry and interconnected government agencies.

The online manifesto of Max Azzarello – the man who self-immolated on the steps of a New York courthouse in April 2024– railed against a conspiracy allegedly including every president since Bill Clinton, sex offender Jeffrey Epstein, even the writers of “The Simpsons.”

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Remember that the more people who supposedly know a secret, the harder it is to keep.

Step 4: Look for a motive

Confirmed conspiracies tell stories about why a group of people acted as they did and what they hoped to gain. Dubious conspiracies involve a lot of accusations or just questions without examining what real benefit the conspiracy nets the conspirators, especially when factoring in the costs.

For instance, what purpose would NASA have to lie about the existence of Finland?

Be particularly suspicious when conspiracies allege an “agenda” being perpetrated by an entire sociodemographic, which is often a marginalized group, such as a “gay agenda” or “Muslim agenda.”

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Also look to see whether those spreading the conspiracy theories have something to gain. For example, scholarly research has identified the 12 people who are the primary sources of false claims about vaccinations. The researchers also found that those people profit from making those claims.

Step 5: Seek the source of the allegations

If you can't figure out who is at the root of a conspiracy allegation and thus how they came to know what they claim, that is another red flag. Some people say they have to remain anonymous because the conspiracists will take revenge for revealing information. But even so, a conspiracy can usually be tracked back to its source – maybe a social media account, even an anonymous one.

Over time, anonymous sources either come forward or are revealed. For instance, years after the Watergate scandal took down Richard Nixon's presidency, a key inside source known as “Deep Throat” was revealed to be Mark Felt, who had been a high-level FBI official in the early 1970s.

Even the notorious “Q” at the heart of the QAnon conspiracy cult has been identified, and not by government investigators chasing leaks of national secrets. Surprise! Q is not the high-level official some people believed.

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Reliable sources are transparent.

A view of a person holding a flashlight standing in a dark field while a circular shape hovers overhead, beaming a light down.

This didn't happen.

David Wall/Moment via Getty Images

Step 6: Beware the supernatural

Some conspiracy theories – though none that have been proven – involve paranormal, alien, demonic or other supernatural forces. People alive in the 1980s and 1990s might remember the public fear that satanic cults were abusing and sacrificing children. That idea never disappeared entirely.

And around the same time, perhaps inspired by the TV “V,” some Americans began to believe in lizard people. It may seem harmless to keep hoping for evidence of Bigfoot, but the person who detonated a bomb in downtown Nashville on Dec. 25, 2020, apparently believed lizard people ran the Earth.

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The closer the conspiracy is to science fiction, the closer it is to just being fiction.

Step 7: Look for other warning signs

There are other red flags too, like the use of prejudicial tropes about the group allegedly behind the conspiracy, particularly antisemitic allegations.

But rather than doing the work to really examine their conspiratorial beliefs, believers often choose to write off the skeptics as fools or as also being in on it – whatever “it” may be.

Ultimately, that's part of the allure of conspiracy theories. It is easier to dismiss criticism than to admit you might be wrong.The Conversation

H. Colleen Sinclair, Associate Research Professor of Social Psychology, Louisiana State University

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This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Future pandemics will have the same human causes as ancient outbreaks − lessons from anthropology can help prevent them

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theconversation.com – Ron Barrett, Associate Professor of Anthropology, Macalester College – 2024-05-07 07:33:36

The changes that came with the transition from foraging to farming paved the way for disease.

Nastasic/DigitalVision Vectors via Getty Images

Ron Barrett, Macalester College

The last pandemic was bad, but is only one of many infectious diseases that emerged since the turn of this century.

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Since 2000, the world has experienced 15 novel Ebola epidemics, the global spread of a 1918-like influenza strain and major outbreaks of three new and unusually deadly coronavirus infections: SARS, MERS and, of course, COVID-19. Every year, researchers discover two or three entirely new pathogens: the viruses, bacteria and microparasites that sicken and kill people.

While some of these discoveries reflect better detection methods, genetic studies confirm that most of these pathogens are indeed new to the human species. Even more troubling, these diseases are appearing at an increasing rate.

Despite the novelty of these particular infections, the primary factors that led to their emergence are quite ancient. Working in the field of anthropology, I have found that these are primarily human factors: the ways we feed ourselves, the ways we together, and the ways we treat one another. In a forthcoming book, “Emerging Infections: Three Epidemiological Transitions from Prehistory to the Present,” my colleagues and I examine how these same elements have influenced disease dynamics for thousands of years. Twenty-first century technologies have served only to magnify ancient challenges.

Neolithic infections

The first major wave of newly emerging infections occurred with the start of the Neolithic revolution about 12,000 years ago, when people began shifting from foraging to farming as their primary means of subsistence.

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Before then, human infections tended to be mild and chronic in nature, manageable burdens of long-term parasites that people carried around from place to place. But full-time agrarian living brought the kinds of acute and virulent infections that we are familiar with . This global shift was humanity's first epidemiological transition.

illustration of an Egyptian tomb engraving of farmers with domesticated animals

The first emerging infections followed the rise of intensive agriculture.

mikroman6/Moment via Getty Images

Farming itself was not the cause. Rather, it was the major lifestyle changes associated with this new enterprise. Agriculture supplied people with high-calorie grains, but often did so at the expense of dietary diversity, resulting in compromised immunity from nutritional deficiencies.

The human population increased dramatically, and so did the number of large and densely settled communities that could sustain the transmission of deadlier pathogens.

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Our ancient ancestors domesticated animals for food and labor, and their proximity to one another created opportunities for livestock diseases to evolve into human diseases.

Finally, the social hierarchies of newly agrarian societies led to disparities in the distribution of essential resources for healthy living.

These challenges of subsistence, settlement and social organization were the root causes of humanity's first major disease transition.

Declining infections

For a dozen millennia, these patterns spread across the world like a plague of plagues. They persisted until the 19th and 20th centuries, when expectancy rose with the precipitous decline of infectious diseases in high- and middle-income countries.

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Remarkably, the greatest proportion of this decline occurred before the discovery of effective antibiotics and most of the vaccines we use today. improvements were mainly due to nonmedicinal factors such as better farming and food distribution methods, major sanitation projects and housing reforms in poor urban areas.

Etching of unhygienic street conditions in 1800s New York City

Urban sanitation did more than new medicines to reduce infections in the 19th century.

Bettmann via Getty Images

These were significant reversals in the same ancient categories – subsistence, settlement and social organization – that led to the rise of infectious diseases in the first place. They resulted in humanity's second epidemiological transition, a significant but only partial reversal of the changes that first began in the Neolithic period.

This second pattern was not a panacea. Despite overall health improvements, chronic noninfectious conditions such as heart disease and cancer rose to become the primary causes of human mortality.

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Most low-income countries experienced a later version of this transition after World War II, but their health gains from declining infections were significantly less than those of their wealthier counterparts. At the same time, their losses to noninfectious diseases rose at comparable rates. These conflicting trends have led to a “worst-of-all-worlds” scenario with respect to the health of poor societies.

It is also worth noting that the declining infections in low-income societies have depended more on affordable antimicrobial drugs. Given the emergence of drug-resistant pathogens, these medicinal buffers are proving to be little more than short-term for the health consequences of poverty.

With the ability of pathogens to move freely across borders and boundaries, these consequences can quickly become everyone's problems.

part of Earth from space showing lines like flightpaths connecting cities

Every corner of the globe is connected by modern travel.

fotograzia/Moment via Getty Images

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Converging infections

In recent decades, humanity's interconnections have reached the point that nearly everyone now lives within a single global disease . Borders and boundaries no longer constrain the spread of distant outbreaks. The COVID-19 pandemic dramatically illustrated this new reality, when the SARS-CoV-2 virus spread around the world in only a few weeks.

The COVID-19 pandemic also highlighted the ways that infectious and noninfectious diseases can interact synergistically with one another to produce even worse outcomes than the simple sum of each disease. This is starkly illustrated by the majority of COVID-19 deaths, which occurred among people with chronic heart, lung and metabolic conditions that are common to a growing proportion of older people in populations both wealthy and poor.

When combined, these challenges have set the stage for the converging disease patterns visible today. This is the third epidemiological transition: the rise of new, virulent and drug-resistant infections occurring in a rapidly aging and highly interconnected world.

Unfortunately, the present pattern entails increasing outbreaks of new and deadly infections. The root causes of these outbreaks are in such as commercial agricultural practices, the urbanization of human populations and the challenges of poverty in the face of economic growth.

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Despite the magnitude of these determinants, they are essentially the same issues of subsistence, settlement and social organization from 12,000 years ago. Addressing these recurring issues will do more than prepare the world for future pandemics; it will to prevent them from in the first place.The Conversation

Ron Barrett, Associate Professor of Anthropology, Macalester College

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Venus is losing water faster than previously thought – here’s what that could mean for the early planet’s habitability

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theconversation.com – Eryn Cangi, Research Scientist in Astrophysical & Planetary Sciences, of Colorado Boulder – 2024-05-06 11:19:38
An artist's illustration of hydrogen disappearing from Venus.
Aurore Simonnet/ Laboratory for Atmospheric and Physics/ University of Colorado Boulder

Eryn Cangi, University of Colorado Boulder

, the atmosphere of our neighbor planet Venus is as hot as a pizza oven and drier than the driest desert on Earth – but it wasn't always that way.

Billions of years ago, Venus had as much water as Earth does today. If that was ever liquid, Venus may have once been habitable.

Over time, that water has nearly all been lost. Figuring out how, when and why Venus lost its water helps planetary scientists like me understand what makes a planet habitable — or what can make a habitable planet transform into an uninhabitable world.

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Venus, with clouds visible on its surface, photographed using UV light.
Venus, Earth's solar system neighbor.
JAXA/ISAS/DARTS/Kevin M. Gill, CC BY

Scientists have theories explaining why most of that water disappeared, but more water has disappeared than they predicted.

In a May 2024 study, my colleagues and I revealed a new water removal process that has gone unnoticed for decades, but could explain this water loss mystery.

Energy balance and early loss of water

The solar system has a habitable zone – a narrow ring around the Sun in which planets can have liquid water on their surface. Earth is in the middle, Mars is outside on the too-cold side, and Venus is outside on the too-hot side. Where a planet sits on this habitability spectrum depends on how much energy the planet gets from the Sun, as well as how much energy the planet radiates away.

The theory of how most of Venus' water loss occurred is tied to this energy balance. On early Venus, sunlight broke up water in its atmosphere into hydrogen and oxygen. Atmospheric hydrogen heats up a planet — like too many blankets on the bed in summer.

When the planet gets too hot, it throws off the blanket: the hydrogen escapes in a flow out to space, a process called hydrodynamic escape. This process removed one of the key ingredients for water from Venus. It's not known exactly when this process occurred, but it was likely within the first years or so.

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Hydrodynamic escape stopped after most hydrogen was removed, but a little bit of hydrogen was left behind. It's like dumping out a water bottle – there will still be a few drops left at the bottom. These leftover drops can't escape in the same way. There must be some other process still at work on Venus that continues to hydrogen.

Little reactions can make a big difference

Our new study reveals that an overlooked chemical reaction in Venus' atmosphere can produce enough escaping hydrogen to close the gap between the expected and observed water loss.

Here's how it works. In the atmosphere, gaseous HCO⁺ molecules, which are made up of one atom each of hydrogen, carbon and oxygen and have a positive charge, combine with negatively charged electrons, since opposites attract.

But when the HCO⁺ and the electrons react, the HCO⁺ breaks up into a neutral carbon monoxide molecule, CO, and a hydrogen atom, H. This process energizes the hydrogen atom, which can then exceed the planet's escape velocity and escape to space. The whole reaction is called HCO⁺ dissociative recombination, but we like to call it DR for short.

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Water is the original source of hydrogen on Venus, so DR effectively dries out the planet. DR has likely happened throughout the history of Venus, and our work shows it probably still continues into the present day. It doubles the amount of hydrogen escape previously calculated by planetary scientists, upending our understanding of present-day hydrogen escape on Venus.

Understanding Venus with data, models and Mars

To study DR on Venus we used both computer modeling and data analysis.

The modeling actually began as a Mars . My Ph.D. research involved exploring what sort of conditions made planets habitable for . Mars also used to have water, though less than Venus, and also lost most of it to space.

To understand martian hydrogen escape, I developed a computational model of the Mars atmosphere that simulates Mars' atmospheric chemistry. Despite being very different planets, Mars and Venus actually have similar upper atmospheres, so my colleagues and I were able to extend the model to Venus.

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We found that HCO⁺ dissociative recombination produces lots of escaping hydrogen in both planets' atmospheres, which agreed with measurements taken by the Mars Atmosphere and Volatile EvolutioN, or MAVEN, mission, a satellite orbiting Mars.

A spacecraft that looks like a metal box with two solar panels attached on either side and a small limb extending downward.
An illustration of the MAVEN mission orbiting Mars.
NASA's Goddard Space Flight Center

Having data collected in Venus' atmosphere to back up the model would be valuable, but previous missions to Venus haven't measured HCO⁺ – not because it's not there, but because they weren't designed to detect it. They did, however, measure the reactants that produce HCO⁺ in Venus' atmosphere.

By analyzing measurements made by Pioneer Venus, a combination orbiter and probe mission that studied Venus from 1978-1992, and using our knowledge of chemistry, we demonstrated that HCO⁺ should be present in the atmosphere in similar amounts to our model.

Follow the water

Our work has filled in a piece of the puzzle of how water is lost from planets, which affects how habitable a planet is for life. We've learned that water loss happens not just in one fell swoop, but over time through a combination of methods.

Faster hydrogen loss today via DR means that less time is required overall to remove the remaining water from Venus. This means that if oceans were ever present on early Venus, they could have been present for longer than scientists thought before water loss through hydrodynamic escape and DR started. This would more time for possible life to arise. Our results don't mean oceans or life were definitely present, though – answering that question will require lots more science over many years.

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There is also a need for new Venus missions and observations. Future Venus missions will provide some atmospheric measurements, but they won't focus on the upper atmosphere where most HCO⁺ dissociative recombination takes place. A future Venus upper atmosphere mission, similar to the MAVEN mission at Mars, could vastly expand everyone's knowledge of how terrestrial planets' atmospheres form and evolve over time.

With the technological advancements of recent decades and a flourishing new interest in Venus, now is an excellent time to turn our eyes toward Earth's sister planet.The Conversation

Eryn Cangi, Research Scientist in Astrophysical & Planetary Sciences, University of Colorado Boulder

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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