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Gene therapy maker Sarepta tells FDA it won’t halt shipments despite patient deaths

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www.clickorlando.com – Matthew Perrone, Associated Press – 2025-07-19 08:20:00

SUMMARY: Sarepta Therapeutics refused the FDA’s request to halt shipments of its gene therapy Elevidys after three patient deaths linked to liver injury. The FDA’s unusual move followed concerns over safety, particularly for older Duchenne muscular dystrophy patients. Elevidys, the first U.S.-approved gene therapy for this fatal muscle-wasting disease, received accelerated approval despite initial doubts about effectiveness. Sarepta halted sales for older patients but plans to keep the drug available for younger ones. The company confirmed a third death in an experimental trial, prompting the FDA to pause that study. Sarepta faces criticism over transparency and has recently cut 500 jobs amid plummeting stock value.

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What to know about arson and explosives units after blast at training facility in Los Angeles

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www.news4jax.com – Hallie Golden, Associated Press – 2025-07-19 00:00:00

SUMMARY: Three members of the Los Angeles County Sheriff’s Department’s arson and explosives unit were killed in a blast at the Biscailuz Training Facility. Authorities are investigating whether the explosion was a training accident. These units handle bomb disposal, arson investigations, and threat prevention. Training is rigorous, often through FBI and ATF programs, and includes real-life simulations. Smaller agencies often rely on larger departments for such expertise. Explosives training is inherently dangerous due to unpredictable variables. Past incidents, including a 2021 fireworks explosion in Los Angeles, highlight the risks faced by these specialized teams. The fallen detectives were highly trained and experienced.

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South Florida Weather Forecast 7/18/2025

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www.youtube.com – CBS Miami – 2025-07-18 22:06:04

SUMMARY: South Florida faces an intense heatwave through the weekend with triple-digit heat indices, prompting heat advisories due to high humidity levels. Afternoon temperatures will hover in the low 90s, but the “feels like” temperature will soar to 104-109°F, stressing the body and increasing risks of heat exhaustion and heat stroke. Rain chances are low until midweek when 40-50% coverage of afternoon showers and storms, fueled by a surge of tropical moisture from the Atlantic, will provide some relief. The Atlantic remains mostly clear of tropical development due to dust from Africa. Rip currents have eased from high to moderate, but hydration and sun protection remain vital.

CBS News Miami’s Chief Meteorologist Ivan Cabrera says to expect South Florida’s hottest weekend this summer with no rain and …

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Lake Mary, Windermere Little Leaguers advance in state tournament amid sweltering heat

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www.youtube.com – FOX 35 Orlando – 2025-07-18 21:56:59

SUMMARY: Lake Mary and Windermere Little League teams are advancing in the state tournament in Melbourne, aiming for another shot at the Little League World Series. Lake Mary dominated with a 19-0 shutout, while Windermere won 11-6. Players are battling intense heat, with temperatures reaching a 101-degree heat index. Hydration is a top priority, with water and Gatorade stocked at the field, and players advised to stay cool between games. Both teams, after winning division and sectionals, aim for the state championship this Sunday. Returning manager Jonathan Anderson remains confident, tackling small goals to reach the ultimate victory.

The Lake Mary Little League team is one step closer to defending its title, delivering a dominant 19-0 shutout Friday night as the Florida state tournament got underway under sweltering conditions in Melbourne.

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