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Chemical pollutants can change your skin bacteria and increase your eczema risk − new research explores how

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theconversation.com – Ian Myles, Chief, Epithelial Unit, National Institute of Allergy and Infectious Diseases – 2024-04-22 07:39:19
Certain chemicals in synthetic fabrics such as spandex, nylon and polyester can alter the skin microbiome.
SBenitez/Moment via Getty Images

Ian Myles, National Institute of Allergy and Infectious Diseases

“We haven't had a full night's sleep since our son was born eight years ago,” said Mrs. B, pointing to her son's dry, red and itchy skin.

Her son has had eczema his entire life. Also known as atopic dermatitis, this chronic skin disease affects about 1 in 5 children in the industrialized world. Some studies have found rates of eczema in developing nations to be over thirtyfold lower compared with industrialized nations.

However, rates of eczema didn't spike with the Industrial Revolution, which began around 1760. Instead, eczema in countries such as the U.S., Finland and other countries started rapidly rising around 1970.

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What caused eczema rates to spike?

I am an allergist and immunologist working with a team of researchers to study trends in U.S. eczema rates. Scientists know that factors such as diets rich in processed foods as well as exposure to specific detergents and chemicals increase the risk of developing eczema. Living near factories, major roadways or wildfires increase the risk of developing eczema. Environmental exposures may also from inside the house through paint, plastics, cigarette smoke or synthetic fabrics such as spandex, nylon and polyester.

While researchers have paid a lot of attention to genetics, the best predictor of whether a child will develop eczema isn't in their genes but the environment they lived in for their first few years of life.

There's something in the air

To figure out what environmental changes may have caused a spike in eczema in the U.S., we began by looking for potential eczema hot spots – places with eczema rates that were much higher than the national average. Then we looked at databases from the U.S. Environmental Protection Agency to see which chemicals were most common in those areas.

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For eczema, along with the allergic diseases that routinely develop with it – peanut allergy and asthma – two chemical classes leaped off the page: diisocyanates and xylene.

Diisocyanates were first manufactured in the U.S. around 1970 for the production of spandex, nonlatex foam, paint and polyurethane. The manufacture of xylene also increased around that time, alongside an increase in the production of polyester and other materials.

Row of people wearing masks sewing clothes in a textile factory
Chemicals involved in clothing production can be hazardous to .
andresr/E+ via Getty Images

The chemically active portion of the diisocyanates and xylene molecules are also found in cigarette smoke and wildfires. After 1975, when all new cars became outfitted with a new technology that converted exhaust gas to less toxic chemicals, isocyanate and xylene both became components of automobile exhaust.

Research has found that exposing mice to isocyanates and xylene can directly cause eczema, itch and inflammation by increasing the activity of receptors involved in itch, pain and temperature sensation. These receptors are also more active in mice placed on unhealthy diets. How directly exposing mice to these toxins compares to the typical levels of exposure in people is still unclear.

How and why might these chemicals be linked to rising rates of eczema?

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Skin microbiome and pollution

Every person is coated with millions of microorganisms that on the skin, collectively referred to as the skin microbiome. While researchers don't know everything about how friendly bacteria help the skin, we do know that people need these organisms to produce certain types of lipids, or oils, that keep the skin sealed from the and stave off infection.

You've probably seen moisturizers and other skin products containing ceramides, a group of lipids that play an important role in protecting the skin. The amount of ceramides and related compounds on a child's skin during their first few weeks of life is a consistent and significant predictor of whether they will go on to develop eczema. The less ceramides they have on their skin, the more likely they'll develop eczema.

Person applying ointment to baby's face
The skin microbiome produces lipids commonly found in moisturizers.
FluxFactory/E+ via Getty Images

To see which toxins could prevent production of the beneficial lipids that prevent eczema, my team and I used skin bacteria as canaries in the coal mine. In the lab, we exposed bacteria that directly make ceramides (such as Roseomonas mucosa), bacteria that help the body make its own ceramides (such as Staphylococcus epidermidis) and bacteria that make other beneficial lipids (such as Staphylococcus cohnii) to isocyanates and xylene. We made sure to expose the bacteria to levels of these chemicals that are similar to what people might be exposed to in the real world, such as the standard levels released from a factory or the fumes of polyurethane glue from a hardware store.

We found that exposing these bacteria to isocyanates or xylene led them to stop making ceramides and instead make amino acids such as lysine. Lysine helps protect the bacteria from the harms of the toxins but doesn't the health of ceramides.

We then evaluated how bed sheets manufactured using isocyanates or xylene affect the skin's bacteria. We found that harmful bacteria such as Staphylococcus aureus proliferated on nylon, spandex and polyester but could not survive on cotton or bamboo. Bacteria that help keep skin healthy could live on any fabric, but, just as with air pollution, the amount of beneficial lipids they made dropped to less than half the levels made when grown on fabrics like cotton.

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Addressing pollution's effects on skin

What can be done about the connection between pollution and eczema?

Detectors capable of sensing low levels of isocyanate or xylene could help track pollutants and predict eczema flare-ups across a community. Better detectors can also help researchers identify air filtration that can scrub these chemicals from the environment. Within the U.S., people can use the EPA Toxics Tracker to look up which pollutants are most common near their home.

In the meantime, improving your microbial balance may require avoiding products that limit the growth of healthy skin bacteria. This may include certain skin care products, detergents and cleansers. Particularly for kids under 4, avoiding cigarette smoke, synthetic fabrics, nonlatex foams, polyurethanes and some paints may be advised.

Replacing bacteria that has been overly exposed to these chemicals may also help. For example, my research has shown that applying Roseomonas mucosa, a ceramide-producing bacterium that lives on healthy skin, can to a monthslong reduction in typical eczema symptoms compared with placebo. Researchers are also studying other potential probiotic treatments for eczema.

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Evaluating the environmental causes of diseases that have become increasingly common in an increasingly industrialized world can help protect from chemical triggers of conditions such as eczema. I believe that it may one day allow us to get back to a time when these diseases were uncommon.The Conversation

Ian Myles, Chief, Epithelial Therapeutics Unit, National Institute of Allergy and Infectious Diseases

This article is republished from The Conversation under a Creative Commons license. Read the original article.

The Conversation

AI chatbots are intruding into online communities where people are trying to connect with other humans

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theconversation.com – Casey Fiesler, Associate Professor of Information Science, University of Colorado Boulder – 2024-05-20 07:27:05
AI chatbots are butting into human spaces.
gmast3r/iStock via Getty Images

Casey Fiesler, University of Colorado Boulder

A parent asked a question in a private Facebook group in April 2024: Does anyone with a child who is both gifted and disabled have any experience with New York City ? The parent received a seemingly helpful answer that laid out some characteristics of a specific school, beginning with the context that “I have a child who is also 2e,” meaning twice exceptional.

On a Facebook group for swapping unwanted items near Boston, a user looking for specific items received an offer of a “gently used” Canon camera and an “almost-new portable air conditioning unit that I never ended up using.”

Both of these responses were lies. That child does not exist and neither do the camera or air conditioner. The answers came from an artificial intelligence chatbot.

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According to a Meta help page, Meta AI will respond to a post in a group if someone explicitly tags it or if someone “asks a question in a post and no one responds within an hour.” The feature is not yet available in all regions or for all groups, according to the page. For groups where it is available, “admins can turn it off and back on at any time.”

Meta AI has also been integrated into search features on Facebook and Instagram, and users cannot turn it off.

As a researcher who studies both online communities and AI ethics, I find the idea of uninvited chatbots answering questions in Facebook groups to be dystopian for a number of reasons, starting with the fact that online communities are for people.

Human connections

In 1993, Howard Rheingold published the book “The Virtual Community: Homesteading on the Electronic Frontier” about the WELL, an early and culturally significant online community. The first chapter opens with a parenting question: What to do about a “blood-bloated thing sucking on our baby's scalp.”

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Rheingold received an answer from someone with firsthand knowledge of dealing with ticks and had resolved the problem before receiving a callback from the pediatrician's office. Of this experience, he wrote, “What amazed me wasn't just the speed with which we obtained precisely the information we needed to know, right when we needed to know it. It was also the immense inner sense of security that with discovering that real people – most of them parents, some of them nurses, doctors, and midwives – are available, around the clock, if you need them.”

This “real people” aspect of online communities continues to be critical . Imagine why you might pose a question to a Facebook group rather than a search engine: because you want an answer from someone with real, lived experience or you want the human response that your question might elicit – sympathy, outrage, commiseration – or both.

Decades of research suggests that the human component of online communities is what makes them so valuable for both information-seeking and social . For example, fathers who might otherwise feel uncomfortable asking for parenting advice have found a haven in private online spaces just for dads. LGBTQ+ youth often join online communities to safely find critical resources while reducing feelings of isolation. Mental support forums provide young people with belonging and validation in addition to advice and social support.

Online communities are well-documented places of support for LGBTQ+ people.

In addition to similar findings in my own lab related to LGBTQ+ participants in online communities, as well as Black Twitter, two more recent studies, not yet peer-reviewed, have emphasized the importance of the human aspects of information-seeking in online communities.

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One, led by PhD student Blakeley Payne, focuses on fat people's experiences online. Many of our participants found a lifeline in access to an audience and community with similar experiences as they sought and shared information about topics such as navigating hostile systems, finding clothing and dealing with cultural biases and stereotypes.

Another, led by Ph.D student Faye Kollig, found that people who share content online about their chronic illnesses are motivated by the sense of community that comes with shared experiences, as well as the humanizing aspects of connecting with others to both seek and support and information.

Faux people

The most important benefits of these online spaces as described by our participants could be drastically undermined by responses coming from chatbots instead of people.

As a type 1 diabetic, I follow a number of related Facebook groups that are frequented by many parents newly navigating the challenges of caring for a young child with diabetes. Questions are frequent: “What does this mean?” “How should I handle this?” “What are your experiences with this?” Answers from firsthand experience, but they also typically come with compassion: “This is hard.” “You're doing your best.” And of course: “We've all been there.”

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A response from a chatbot claiming to speak from the lived experience of caring for a diabetic child, offering empathy, would not only be inappropriate, but it would be borderline cruel.

However, it makes complete sense that these are the types of responses that a chatbot would offer. Large language models, simplistically, function more similarly to autocomplete than they do to search engines. For a model trained on the millions and millions of posts and comments in Facebook groups, the “autocomplete” answer to a question in a support community is definitely one that invokes personal experience and offers empathy – just as the “autocomplete” answer in a Buy Nothing Facebook group might be to offer someone a gently used camera.

Meta has rolled out an AI assistant across its social media and messaging apps.

Keeping chatbots in their lanes

This isn't to suggest that chatbots aren't useful for anything – they may even be quite useful in some online communities, in some contexts. The problem is that in the midst of the current generative AI rush, there is a tendency to think that chatbots can and should do everything.

There are plenty of downsides to using large language models as information retrieval systems, and these downsides point to inappropriate contexts for their use. One downside is when incorrect information could be dangerous: an eating disorder helpline or legal advice for small businesses, for example.

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Research is pointing to important considerations in how and when to design and deploy chatbots. For example, one recently published paper at a large human-computer interaction conference found that though LGBTQ+ individuals lacking social support were sometimes turning to chatbots for help with mental health needs, those chatbots frequently fell short in grasping the nuance of LGBTQ+-specific challenges.

Another found that though a group of autistic participants found value in interacting with a chatbot for social communication advice, that chatbot was also dispensing questionable advice. And yet another found that though a chatbot was helpful as a preconsultation tool in a health context, sometimes found expressions of empathy to be insincere or offensive.

Responsible AI and deployment means not only auditing for issues such as bias and misinformation, but also taking the time to understand in which contexts AI is appropriate and desirable for the humans who will be interacting with them. Right now, many companies are wielding generative AI as a hammer, and as a result, everything looks like a nail.

Many contexts, such as online support communities, are best left to humans.The Conversation

Casey Fiesler, Associate Professor of Information Science, University of Colorado Boulder

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The Conversation

Is hard water bad for you? 2 water quality engineers explain the potential benefits and pitfalls that come with having hard water

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theconversation.com – Sarah Blank, Master's Student in Civil Engineering, Iowa State – 2024-05-20 07:26:46
Do you know how hard your is?
Tatiana Maksimova/Moment via Getty Images

Sarah Blank, Iowa State University and Timothy Ellis, Iowa State University

When you turn on your faucet to get a glass of water or wash your face, you're probably not thinking about what's in your water – besides water. Depending on where you and whether you have a water-softening system, your water might contain dissolved minerals such as calcium and magnesium. And these minerals can play a role in whether certain pollutants such as lead stay out of your water.

The more dissolved minerals, the “harder” your water. But is hard water actually good or bad for you?

As engineering researchers who study water quality, we have seen the effects – both good and bad – that soft and hard water can have on everything from plumbing to the human body.

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What is hard water?

Hard water is water that contains dissolved minerals such as calcium, magnesium, iron and manganese. Soft water contains lower concentrations of these minerals.

Hardness is measured in terms of calcium carbonate, CaCO₃, which is used as a reference point for comparing different minerals.

The amount of these minerals in a 's water supply varies by region. It depends on both where the water is coming from and how the water is treated.

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Communities that source their water from wells rather than surface water such as lakes, streams, rivers and reservoirs often start with hard water pretreatment. As groundwater moves through the soil to a well, it picks up minerals. At the same time, where the types of rock and sediment are more prone to dissolving in water may have harder water.

A map showing water hardness across the U.S., with the hardest water in the Midwest, West and Southwest.
Streamflow water hardness across the U.S., where purple and blue indicate softer water and white and red indicate harder water. This map was updated in 2005 by the U.S. EPA.
U.S. Geological Survey

Effects on water lines and distribution

Water that's too hard or too soft could damage pipes and lead to health and aesthetic concerns.

Since hard water has a higher mineral concentration, minerals can build up in pipes, which leads to clogged pipes in homes and public water systems. Hardness also creates more deposits at higher temperatures, so hot water heaters are prone to mineral buildup. In areas with hard water, water heaters have a shorter life span.

A pipe with gray material around the inside.
A pipe that has a thick layer of mineral deposits inside of it.
Mevedech/Wikimedia Commons

But hard water can , too. While minerals from hard water can clog pipes, a thin layer of mineral deposition in water lines can protect you from ingesting toxins that could seep in from the pipe itself. Water without any minerals can play a role in pipe corrosion, because without a thin, protective layer of minerals, the water may start to eat away at the pipes, releasing metals from the pipes into the water. Drinking this water might mean ingesting metals such as lead, copper and iron.

While water that is too soft or too hard can have different effects on water lines, there is more chemistry than just hardness that plays a role in pipe corrosion and clogging. So, there's no specific hardness level that is a cause for concern. Water treatment plants take the appropriate measures to adjust for different hardness levels.

A large tank of water, with fences around the top.
Drinking water normally undergoes treatment at a plant before it makes its way to your home.
Florida Water Daily, CC BY

Effects on skin and hair

Whether you use hard or soft water to wash up can also have noticeable effects on your skin and hair.

Hard water is more likely to leave your skin dry. The minerals in hard water strip moisture from skin and create deposits that clog pores.

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Hard water can also strip the hair of moisture, leaving it dry and coarse. Dry hair is more prone to frizz, tangles and breakage. Mineral deposits can also build up on the hair and scalp, clogging your hair follicles and leading to dandruff and slowed hair growth.

Many households have their own water-softening systems. A water-softening system may help hair and skin dryness and buildup. But many of these systems trap and replace calcium and magnesium with sodium, a mineral that does not contribute to water hardness, to lower overall hardness. Increasing the water's sodium content may be a concern for anyone on a low-sodium diet.

Overall health benefits

Other than aesthetic and water heater concerns, drinking hard water is actually good for you and doesn't with any serious adverse side effects.

For example, the extra magnesium and calcium you consume in hard water may a gentle solution to digestive issues and constipation.

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Also, researchers have found positive correlations between the hardness of drinking water and bone health. Since calcium is an essential mineral in bones, individuals in areas with drinking water that has more calcium may have higher bone mineral density and may be less prone to osteoporosis.

Researchers have also found that drinking hard water has been associated with a decrease in cardiovascular disease-related mortality. Magnesium helps regulate your cardiac muscles, while calcium keeps the sodium-potassium balance in your cardiac muscles in check, which they need to function.

Whether you have hard or soft water, don't worry too much. Water treatment plants take appropriate measures to ensure safe water for the communities they .

To learn more about the water hardness in your area, you can contact your local water treatment plant about its specific water treatment process. Private well owners can contact their state government to find out the testing recommendations for their area.The Conversation

Sarah Blank, Master's Student in Civil Engineering, Iowa State University and Timothy Ellis, Associate Professor of Civil, Construction and Environmental Engineering, Iowa State University

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Black holes are mysterious, yet also deceptively simple − a new space mission may help physicists answer hairy questions about these astronomical objects

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theconversation.com – Gaurav Khanna, Professor of Physics, of Rhode Island – 2024-05-15 07:16:18

An illustration of a supermassive black hole.

NASA/JPL

Gaurav Khanna, University of Rhode Island

Physicists consider black holes one of the most mysterious objects that exist. Ironically, they're also considered one of the simplest. For years, physicists like me have been looking to prove that black holes are more complex than they seem. And a newly approved European space mission called LISA will us with this hunt.

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Research from the 1970s suggests that you can comprehensively describe a black hole using only three physical attributes – their mass, charge and spin. All the other properties of these massive dying , like their detailed composition, density and temperature profiles, disappear as they transform into a black hole. That is how simple they are.

The idea that black holes have only three attributes is called the “no-hair” theorem, implying that they don't have any “hairy” details that make them complicated.

Black holes are massive, mysterious astronomical objects.

Hairy black holes?

For decades, researchers in the astrophysics community have exploited loopholes or work-arounds within the no-hair theorem's assumptions to up with potential hairy black hole scenarios. A hairy black hole has a physical property that scientists can measure – in principle – that's beyond its mass, charge or spin. This property has to be a permanent part of its structure.

About a decade ago, Stefanos Aretakis, a physicist currently at the University of Toronto, showed mathematically that a black hole containing the maximum charge it could hold – called an extremal charged black hole – would develop “hair” at its horizon. A black hole's horizon is the boundary where anything that crosses it, even light, can't escape.

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Aretakis' analysis was more of a thought experiment using a highly simplified physical scenario, so it's not something scientists expect to observe astrophysically. But supercharged black holes might not be the only kind that could have hair.

Since astrophysical objects such as stars and planets are known to spin, scientists expect that black holes would spin as well, based on how they form. Astronomical evidence has shown that black holes do have spin, though researchers don't know what the typical spin value is for an astrophysical black hole.

Using computer simulations, my team has recently discovered similar types of hair in black holes that are spinning at the maximum rate. This hair has to do with the rate of change, or the gradient, of -time's curvature at the horizon. We also discovered that a black hole wouldn't actually have to be maximally spinning to have hair, which is significant because these maximally spinning black holes probably don't form in nature.

Detecting and measuring hair

My team wanted to develop a way to potentially measure this hair – a new fixed property that might characterize a black hole beyond its mass, spin and charge. We started looking into how such a new property might a signature on a gravitational wave emitted from a fast-spinning black hole.

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A gravitational wave is a tiny disturbance in space-time typically caused by violent astrophysical in the universe. The collisions of compact astrophysical objects such as black holes and neutron stars emit strong gravitational waves. An international network of gravitational observatories, the Laser Interferometer Gravitational-wave Observatory in the United States, routinely detects these waves.

Our recent studies suggest that one can measure these hairy attributes from gravitational wave data for fast-spinning black holes. Looking at the gravitational wave data offers an for a signature of sorts that could indicate whether the black hole has this type of hair.

Our ongoing studies and recent progress made by Som Bishoyi, a student on the team, are based on a blend of theoretical and computational models of fast-spinning black holes. Our findings have not been tested in the field yet or observed in real black holes out in space. But we hope that will soon change.

LISA gets a go-ahead

In January 2024, the European Space Agency formally adopted the space-based Laser Interferometer Space Antenna, or LISA, mission. LISA will look for gravitational waves, and the data from the mission could help my team with our hairy black hole questions.

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Three spacecrafts spaced apart sending light beams towards each other while orbiting the Sun

The LISA spacecrafts observing gravitational waves from a distant source while orbiting the Sun.

Simon Barke/Univ. Florida, CC BY

Formal adoption means that the has the go-ahead to move to the construction phase, with a planned 2035 launch. LISA consists of three spacecrafts configured in a perfect equilateral triangle that will trail behind the Earth around the Sun. The spacecrafts will each be 1.6 million miles (2.5 million kilometers) apart, and they will exchange laser beams to measure the distance between each other down to about a billionth of an inch.

LISA will detect gravitational waves from supermassive black holes that are millions or even billions of times more massive than our Sun. It will build a map of the space-time around rotating black holes, which will help physicists understand how gravity works in the close vicinity of black holes to an unprecedented level of accuracy. Physicists hope that LISA will also be able to measure any hairy attributes that black holes might have.

With LIGO making new observations every day and LISA to offer a glimpse into the space-time around black holes, now is one of the most exciting times to be a black hole physicist.The Conversation

Gaurav Khanna, Professor of Physics, University of Rhode Island

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